Brucella melitensis ATCC 23457

Gram-negativeCocciNon-motileFacultative aerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Alphaproteobacteria

Order

Hyphomicrobiales

Family

Brucellaceae

Genus

Brucella

Description

Brucella melitensis ATCC 23457 is a Gram-negative bacterium with a cocci shape, typically arranged in chains, pairs, or as singles. This organism is a facultative aerobe, allowing it to thrive in environments with varying oxygen levels. It is non-motile and does not possess flagella, which is consistent with its stationary lifestyle. B. melitensis is mesophilic, with an optimal growth temperature of 37°C, which aligns with the body temperature of its primary hosts. This bacterium is known to be pathogenic, particularly affecting livestock and potentially humans, leading to brucellosis, a significant zoonotic disease. The organism features a unique cellular structure with two membranes and a single replicon, characteristics that are typical of the Brucella genus. It is nonsporulating, indicating that it does not form spores as a survival mechanism. In terms of its ecological role, B. melitensis is primarily host-associated, indicating a close relationship with its animal hosts. Its free-living biotic relationship suggests that it may also exist in the environment, albeit in a limited capacity, outside of its host. Understanding the characteristics of Brucella melitensis ATCC 23457 enhances our knowledge of its pathogenic potential and ecological interactions, emphasizing the importance of monitoring this bacterium in both agricultural and public health contexts.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassAlphaproteobacteria
OrderHyphomicrobiales
FamilyBrucellaceae
GenusBrucella
SpeciesBrucella melitensis
StrainATCC 23457

Profile

Physiology
Gram staining propertiesNegative
ShapeCocci
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Brucella melitensis ATCC 23457
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative aerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementChains - Pairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Brucella melitensis ATCC 23457


Gene Summary

Adenine Count

252295 bp

Thymine Count

253385 bp

Guanine Count

339531 bp

Cytosine Count

340307 bp

Genome Length

1185518 bp

Protein-coding Genes

1111 genes

Non-Coding Genes

17 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenaseBMEA_RS10355Not AvailableNegative10398 - 1117427148.8
isochorismataseBMEA_RS10360Not AvailableNegative11174 - 1204632588.2
(2,3-dihydroxybenzoyl)adenylate synthaseBMEA_RS10365Not AvailableNegative12098 - 1371758759.6
isochorismate synthase menfBMEA_RS10370Not AvailableNegative13824 - 1499942498.7
condensation domain-containing proteinBMEA_RS10375Not AvailablePositive15140 - 1648050407.3
molybdopterin-dependent oxidoreductaseBMEA_RS10380Not AvailableNegative16528 - 1731628970.2
cytochrome b/b6 domain-containing proteinBMEA_RS10385Not AvailableNegative17313 - 1812230285.0
pentapeptide mxkdx repeat proteinBMEA_RS10390Not AvailableNegative18185 - 184549626.75
sigma-70 family rna polymerase sigma factorBMEA_RS10395Not AvailablePositive18651 - 1916319054.0
nrsf family proteinBMEA_RS10400Not AvailablePositive19153 - 1978822537.5

Displaying genes 11 – 20 of 1128 in total

Metabolites

1788 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm0000274aldehydo-D-galacturonateC6H9O7Chemical structure of aldehydo-D-galacturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000401(S)-2-succinylamino-6-oxoheptanedioateC11H12NO8Chemical structure of (S)-2-succinylamino-6-oxoheptanedioateNot available
Average286.218Da
Monoisotopic286.0579371Da

Displaying 1–10 of 1788 metabolites

Health Effects

No health effects information available for this bacterium.