Helicobacter pylori P12

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori P12 is a microaerophilic, gram-negative bacterium characterized by its spirilla shape and the presence of flagella. This organism is typically found in host-associated environments, where it exhibits a free-living biotic relationship. It has an optimal growth temperature of 37°C and falls within the mesophilic temperature range. H. pylori P12 has a unique genomic structure with two replicons and features a double membrane system. Importantly, this bacterium does not undergo sporulation, which is a common survival mechanism in many microorganisms. Its pathogenicity is notable, as H. pylori is recognized as a significant contributor to gastrointestinal diseases, including peptic ulcers and chronic gastritis. The cell arrangement of H. pylori P12 consists of single cells, which allows for individual mobility within the gastric niche it occupies. The presence of flagella aids in its motility, enabling the bacterium to navigate the viscous environment of the stomach. Understanding H. pylori P12's specific traits highlights its adaptability and pathogenic potential within the host. Its microaerophilic nature and optimal growth conditions suggest that it has evolved to thrive in the unique chemical and physical environment of the stomach, where it can establish beneficial relationships with the host while also posing health risks. This balance between pathogenicity and host association emphasizes the complexity of microbial interactions in the human gastrointestinal tract.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
StrainP12

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori P12
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementSingles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Helicobacter pylori P12


Gene Summary

Adenine Count

508823 bp

Thymine Count

515400 bp

Guanine Count

323215 bp

Cytosine Count

326375 bp

Genome Length

1673813 bp

Protein-coding Genes

1562 genes

Non-Coding Genes

45 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
transcription antitermination factor nusbHPP12_RS00005Not AvailableNegative13 - 42915550.0
6,7-dimethyl-8-ribityllumazine synthaseHPP12_RS00010Not AvailableNegative431 - 90116941.7
3-deoxy-8-phosphooctulonate synthaseHPP12_RS00015Not AvailableNegative911 - 174130195.4
carbonic anhydraseHPP12_RS00020Not AvailableNegative1728 - 239325731.7
orotidine-5'-phosphate decarboxylaseHPP12_RS00025Not AvailablePositive2515 - 319825323.1
pantoate--beta-alanine ligaseHPP12_RS00030Not AvailablePositive3199 - 402931203.1
Trna-gluNot AvailableNot AvailablePositive4043 - 4118Not Available
Trna-aspNot AvailableNot AvailablePositive4181 - 4257Not Available
Trna-valNot AvailableNot AvailablePositive4298 - 4373Not Available
Trna-gluNot AvailableNot AvailablePositive4415 - 4489Not Available

Displaying genes 1 – 10 of 1617 in total

Metabolites

1668 records
Metabolite IDMetabolite nameStructureCAS number
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm0001661Cu(2+)CuChemical structure of Cu(2+)7440-50-8
Average63.546Da
Monoisotopic62.929601079Da
BASm00016962-heptyl-3-hydroxy-4(1H)-quinoloneC16H21NO2Chemical structure of 2-heptyl-3-hydroxy-4(1H)-quinoloneNot available
Average259.349Da
Monoisotopic259.15722892Da
BASm0001697(S)-4,5-dihydroxypentane-2,3-dioneC5H8O4Chemical structure of (S)-4,5-dihydroxypentane-2,3-dioneNot available
Average132.1146Da
Monoisotopic132.042258744Da

Displaying 1–10 of 1668 metabolites

Health Effects

No health effects information available for this bacterium.