Escherichia coli UTI89

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli UTI89 is a Gram-negative, rod-shaped bacterium that serves as a significant uropathogen in urinary tract infections. This strain is characterized by its facultative anaerobic metabolism, allowing it to thrive in both oxygen-rich and low-oxygen environments. It possesses flagella, granting it mobility, which is crucial for its ability to colonize the urinary tract. UTI89 is adapted to a host-associated habitat, indicating its reliance on a living host for survival and growth. It is nonsporulating and has a single replicon, reflecting its simplicity in genetic structure. The bacterium has two membranes, typical of Gram-negative organisms, which contribute to its pathogenicity. Optimal growth occurs at 37°C, aligning with the human body temperature, and it is classified as mesophilic, indicating its preference for moderate temperature ranges. As a free-living organism, E. coli UTI89 can exist independently outside of its host, yet its pathogenicity underscores its role in urinary infections. This duality in lifestyle highlights the ecological adaptability of this strain, capable of thriving in diverse environments while also posing a risk to human health. Understanding the traits of E. coli UTI89 contributes to broader insights into microbial behavior in host-associated habitats and the mechanisms underlying its pathogenic effects. The accession number for this strain is NC_007946.1.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
StrainUTI89

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli UTI89
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementPairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Escherichia coli UTI89, complete sequence.

Gene Summary

Adenine Count

1250197 bp

Thymine Count

1252067 bp

Guanine Count

1279155 bp

Cytosine Count

1284322 bp

Genome Length

5065741 bp

Protein-coding Genes

4475 genes

Non-Coding Genes

457 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
Trna-asnNot AvailableNot AvailablePositive2113924 - 2113999Not Available
tyrosine-type recombinase/integraseUTI89_RS10735Not AvailablePositive2114161 - 211543248809.2
colibactin self-protection protein clbsUTI89_RS10745Not AvailableNegative2115712 - 211622419651.6
colibactin biosynthesis thioesterase clbqUTI89_RS10750Not AvailableNegative2116259 - 211698127337.0
precolibactin peptidase clbpUTI89_RS10755Not AvailableNegative2116974 - 211848855475.6
colibactin polyketide synthase clboUTI89_RS10760Not AvailableNegative2118501 - 212096089568.7
colibactin non-ribosomal peptide synthetase clbnUTI89_RS10765Not AvailableNegative2120991 - 2125358162080.0
precolibactin export mate transporter clbmUTI89_RS10770Not AvailableNegative2125355 - 212679452865.1
colibactin biosynthesis amidase clblUTI89_RS10775Not AvailableNegative2126856 - 212831953515.7
colibactin hybrid non-ribosomal peptide synthetase/type i polyketide synthase clbkUTI89_RS10780Not AvailableNegative2128312 - 2134776237813.0

Displaying genes 2301 – 2310 of 4932 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

4852 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4852 metabolites

Health Effects

No health effects information available for this bacterium.