Anaeromyxobacter dehalogenans 2CP-C

The delta-Proteobacterium Anaeromyxobacter dehalogenans utilizes halogenated compounds, such as 2-chlorophenol, 2,6-dichlorophenol, 2,5-dichlorophenol, and 2-bromophenol, as growth-supporting electron acceptors (halorespiration). Anaeromyxobacter dehalogenans exhibits metabolic versatility, and grows under a variety of redox conditions. Oxidized metal species such as U(VI) and Fe(III) (including ferric oxyhydroxide), anthraquinone disulfonate (AQDS), halogenated phenols, oxygen, nitrate, nitrite, and fumarate are used in terminal electron accepting processes (TEAPs). Also, Anaeromyxobacter dehalogenans demonstrates great electron donor versatility, and couples electron acceptor reduction to the oxidation of a variety of compounds including formate, hydrogen, acetate, succinate, pyruvate, and glucose. A. dehalogenans tolerates high concentrations of reduced products such as phenol or ammonium and has been found to be the predominant metal reducing populations at uranium-contaminated sites that are characterized by changing redox conditions and low pH. A feature that distinguishes A. dehalogenans from other reductively dechlorinating and metal-reducing populations is this organism's ability to both use acetate and hydrogen as a source of reducing equivalents. Sequencing its genome will provide relevant information regarding reductive dehalogenase genes and the organization of reductive dehalogenase operons. Such information is critical for the design of nucleic acid-based tools to detect, monitor and quantify functional genes involved in reductive dechlorination processes at contaminated sites. (EBI Integr8)