Mycobacterium leprae TN

Gram-positiveBacilliNon-motileAerobic

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Mycobacteriales

Family

Mycobacteriaceae

Genus

Mycobacterium

Description

Mycobacterium leprae TN is a pathogenic, aerobic bacterium characterized by its bacilli shape and positive Gram reaction. It is a chemoorganotroph, meaning it derives its energy from organic compounds. This microorganism is non-motile and does not possess flagella, yet it can still be classified as free-living, indicating a particular relationship with its host. M. leprae TN is adapted to a mesophilic environment, with an optimal growth temperature of 37°C, which corresponds to the human body temperature, highlighting its role as a human pathogen. It has a singular replicon and a single membrane structure, traits that are typical for certain bacteria within its genus. This species is non-sporulating, implying that it does not form spores for survival in adverse conditions, further emphasizing its specialization as a host-associated organism. Its pathogenicity is well-documented, with the bacterium being the causative agent of leprosy, a chronic infectious disease that primarily affects the skin and peripheral nerves. In summary, Mycobacterium leprae TN exemplifies a highly adapted pathogen that thrives in specific host environments, utilizing a specialized metabolic strategy to survive and replicate. Understanding its traits can provide insights into its ecological niche and potential strategies for treatment and prevention of the diseases it causes.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderMycobacteriales
FamilyMycobacteriaceae
GenusMycobacterium
SpeciesMycobacterium leprae
StrainTN

Profile

Physiology
Gram staining propertiesPositive
ShapeBacilli
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Mycobacterium leprae TN
AI-generated image based on bacteria physiology
Ecology, Host, and Life Cycle
Oxygen requirementsAerobic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementSingles
SporulationNonsporulating
Energy sourceChemoorganotroph
PathogenicityYes

Genome Summary

Mycobacterium leprae TN


Gene Summary

Adenine Count

687041 bp

Thymine Count

692247 bp

Guanine Count

950202 bp

Cytosine Count

938713 bp

Genome Length

3268203 bp

Protein-coding Genes

2920 genes

Non-Coding Genes

51 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
amino acid permease c-terminal domain-containing proteinML_RS15325Not AvailablePositive911200 - 9114308952.91
membrane protein insertion efficiency factor yiddML_RS03870Not AvailablePositive912800 - 9129827410.65
membrane protein insertion efficiency factor yiddML_RS15330Not AvailablePositive912955 - 91348617969.4
adenosylhomocysteinaseML_RS03875Not AvailablePositive913623 - 91510153989.2
dtmp kinaseML_RS03880Not AvailablePositive915144 - 91577623026.1
two-component system response regulator mtraML_RS03885Not AvailablePositive915869 - 91655525287.9
mtrab system histidine kinase mtrbML_RS03890Not AvailablePositive916683 - 91837161509.3
mtrab system accessory lipoprotein lpqbML_RS03895Not AvailablePositive918392 - 92013760903.5
membrane protein insertion efficiency factor yiddML_RS03900Not AvailablePositive920230 - 9204558175.92
ribosome hibernation-promoting factor, hpf/yfia familyML_RS03910Not AvailablePositive921028 - 92164223474.9

Displaying genes 821 – 830 of 2971 in total

Metabolites

204 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000642S-adenosyl-4-methylsulfanyl-2-oxobutanoateC15H19N5O6SChemical structure of S-adenosyl-4-methylsulfanyl-2-oxobutanoateNot available
Average397.406Da
Monoisotopic397.105604055Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001210alpha,alpha'-trehalose 6,6'-bismycolateC76H142O15Chemical structure of alpha,alpha'-trehalose 6,6'-bismycolateNot available
Average1295.957Da
Monoisotopic1295.034874Da
BASm0001216alpha,alpha'-trehalose 6-mycolateC44H82O13Chemical structure of alpha,alpha'-trehalose 6-mycolateNot available
Average819.127Da
Monoisotopic818.5755427Da
BASm00012442-succinylbenzoateC11H8O5Chemical structure of 2-succinylbenzoate27415-09-04
Average220.181Da
Monoisotopic220.038270517Da

Displaying 1–10 of 204 metabolites

Health Effects

No health effects information available for this bacterium.