Escherichia coli strain ICBEcBL-II-13

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli strain ICBEcBL-II-13 is a Gram-negative, rod-shaped bacterium that is a facultative anaerobe, exhibiting mobility due to the presence of flagella. This strain is mesophilic, with an optimal growth temperature of 37°C, and it typically exists in pairs or singles. It is host-associated and displays a free-living biotic relationship. This strain has a diverse range of hosts, including Homo sapiens (humans), Gallus gallus (chickens), Bos taurus (cattle), and various other mammals, birds, and even some plants such as Solanum lycopersicum (tomatoes) and Brassica oleracea var. italica (broccoli). Its broad host range suggests that ICBEcBL-II-13 may play a significant ecological role in various environments, potentially influencing microbial communities across different habitats. ICBEcBL-II-13 is associated with numerous health effects in humans, primarily linked to urinary tract infections (UTIs), gastrointestinal infections, and severe outcomes such as hemolytic uremic syndrome (HUS). The strain's pathogenicity is notable, as it can lead to conditions like neonatal meningitis and septicemia, showcasing its impact on human health. The presence of this strain in hosts like mammals and birds indicates its potential for zoonotic transmission and highlights the importance of monitoring its spread in both agricultural and clinical settings. Understanding the pathogenic mechanisms of E. coli strains like ICBEcBL-II-13 is crucial for developing effective interventions against the diseases it may cause.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
Strainstrain ICBEcBL-II-13

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli strain ICBEcBL-II-13
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Bos taurus
Cell arrangementPairs - Singles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Escherichia coli strain ICBEcBL-II-13

Gene Summary

Adenine Count

1232445 bp

Thymine Count

1231303 bp

Guanine Count

1255900 bp

Cytosine Count

1252694 bp

Genome Length

4972342 bp

Protein-coding Genes

5228 genes

Non-Coding Genes

122 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hydrogenase formation protein hypdBXT93_17995Not AvailableNegative3439729 - 344085041367.7
hydrogenase assembly protein hypcBXT93_18000Not AvailableNegative3440850 - 34411229732.58
hydrogenase isoenzymes nickel incorporation protein hypbBXT93_18005Not AvailableNegative3441113 - 344198531566.8
hydrogenase maturation nickel metallochaperone hypaBXT93_18010Not AvailableNegative3441989 - 344235113529.3
formate hydrogenlyase regulatory protein hycaBXT93_18015Not AvailablePositive3442551 - 344301217627.9
hypothetical proteinBXT93_18020Not AvailableNegative3442928 - 344323611381.7
formate hydrogenlyase subunit 2BXT93_18025Not AvailablePositive3443137 - 344374821874.4
formate hydrogenlyase subunit 3BXT93_18030Not AvailablePositive3443745 - 344557164085.1
hydrogenase 3 membrane subunitBXT93_18035Not AvailablePositive3445574 - 344588811398.5
alkene reductaseBXT93_18040Not AvailableNegative3445889 - 344646320465.4

Displaying genes 3531 – 3540 of 5350 in total

Metabolites

4785 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4785 metabolites

Health Effects

Health ConditionRelationReference
Gi diseaseCausesPMC11149725
UtisCausesPMC11434687
Colorectal cancerCausesPMC12198655
Pyogenic liver abscessesCausesPMC12392612
UtiCausesPMC13014981
ColibacillosisCausesPMC13255289
Enteric infectionsCausesPMC13255289
Foodborne infectionsCausesPMC13255289
Clinical mastitisCausesPMC13293316
DiarrheaCausesPMC3035056

Displaying health effects 1 – 10 of 103 in total