Helicobacter pylori strain MM2006-480

Helicobacter pylori strain MM2006-480 is a Gram-negative bacterium with a spirilla shape and is characterized by its microaerophilic oxygen requirement. It has a single replicon, is surrounded by two membranes, and possesses flagella, although it is non-motile. This strain is primarily associated with hosts such as Homo sapiens, Gallus gallus, Aves, Primates, Mammalia, Amoeba, Rodentia, and Cricetinae. The optimal growth temperature for MM2006-480 is 37°C, placing it within the mesophilic temperature range. This strain exhibits a free-living biotic relationship, yet it is well-known for its pathogenic effects in humans, contributing to a range of gastrointestinal diseases. Notably, H. pylori strain MM2006-480 is linked to chronic gastric inflammation, gastric ulcers, and severe conditions like gastric cancer and mucosa-associated lymphoid tissue lymphoma. The bacterium is also associated with functional dyspepsia and various forms of dysplasia, indicating its significant role in gastrointestinal health and disease. The ecological insight provided by this strain highlights the complex interactions between H. pylori and its human host, wherein the presence of the bacterium can lead to both asymptomatic and symptomatic conditions. This duality emphasizes the importance of understanding H. pylori's pathogenic potential and its impact on human health, particularly in the context of chronic diseases such as gastric carcinoma and peptic ulcer disease. The presence of H. pylori in diverse hosts also suggests its adaptability and evolutionary significance in various ecological niches.