Helicobacter pylori strain MGms23

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain MGms23 is a microaerophilic, Gram-negative bacterium classified as a spirilla. It typically exists as single cells and possesses flagella, allowing for motility despite its free-living biotic relationship. This strain is mesophilic, with an optimal growth temperature of 37°C, and it has a unique cellular structure characterized by two membranes and a single replicon. Helicobacter pylori is notably associated with various hosts, including Homo sapiens, Gallus gallus, Aves, Primates, Mammalia, Amoeba, Rodentia, and Cricetinae. The bacterium is well-documented for its pathogenicity in humans, contributing to a range of gastrointestinal diseases. These include chronic gastric inflammation, peptic ulcer disease, and various forms of gastric cancer, such as gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Other health effects linked to this strain include chronic gastritis, dyspepsia, functional dyspepsia, and acute gastric ulcers. Ecologically, H. pylori strain MGms23 plays a significant role in the human microbiome, influencing gastric health and disease. Its presence can lead to both symptomatic conditions and asymptomatic mucosal inflammatory responses, highlighting its complex interactions within host organisms. The strain's ability to thrive in various hosts suggests an adaptable ecological niche, impacting health outcomes across different species. Understanding the traits and effects of H. pylori MGms23 is crucial for addressing its implications in human health, particularly concerning gastrointestinal diseases.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain MGms23

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain MGms23
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain MGms23 MGms23_Contig089, whole genome

Gene Summary

Adenine Count

506701 bp

Thymine Count

510870 bp

Guanine Count

325171 bp

Cytosine Count

322185 bp

Genome Length

1664931 bp

Protein-coding Genes

1472 genes

Non-Coding Genes

43 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
flagellin bBGL77_02485Not AvailableNegative500050 - 50158253287.6
hemolysinBGL77_02495Not AvailablePositive503586 - 50488748406.1
8-amino-7-oxononanoate synthaseBGL77_02500Not AvailablePositive504910 - 50603142043.0
penicillin-binding proteinBGL77_02505Not AvailablePositive506032 - 50801174127.5
tumor necrosis factor alpha-inducing proteinBGL77_02510Not AvailableNegative508014 - 50859221889.7
disulfide bond formation protein dsbbBGL77_02520Not AvailableNegative509067 - 51053955499.2
hypothetical proteinBGL77_02525Not AvailableNegative510549 - 5107136067.77
dihydroorotaseBGL77_02540Not AvailableNegative513095 - 51411438083.4
siderophore-mediated iron transporterBGL77_02545Not AvailableNegative514118 - 51477425322.4
guanylate kinaseBGL77_02555Not AvailablePositive515596 - 51621623857.8

Displaying genes 471 – 480 of 1515 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total