Helicobacter pylori strain MC2011-145

Helicobacter pylori strain MC2011-145 is a microaerophilic, Gram-negative bacterium characterized by its spirilla shape and single-cell arrangement. It possesses flagella, which aids in its mobility, although it is noted that it does not actively move. The strain has an optimal growth temperature of 37°C and falls within the mesophilic temperature range. MC2011-145 is associated with various hosts, including Homo sapiens, Gallus gallus, and multiple other animal groups such as Aves, Primates, and Rodentia, as well as Amoeba. This strain is known for its significant pathogenicity in humans, being linked to a range of gastrointestinal diseases. Health effects associated with H. pylori strain MC2011-145 include chronic gastric inflammation, peptic ulcer disease, acute gastric ulcers, and various types of gastric cancer, including gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. It also contributes to conditions like gastritis and gastroesophageal reflux disease (GERD), highlighting its role in both symptomatic and asymptomatic gastric disorders. The presence of H. pylori in the human stomach is a complex biotic relationship that can lead to chronic inflammation and serious health complications. Its ability to thrive in the host-associated environment indicates its evolutionary adaptation to the gastric mucosa, where it can persist and induce pathologies that significantly impact human health. Understanding the traits of H. pylori strain MC2011-145 underscores its importance in microbial ecology and human health, particularly regarding its role in gastrointestinal diseases.