Helicobacter pylori strain 2029

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain 2029 is a gram-negative, microaerophilic bacterium characterized by its spirilla shape and presence of flagella. It is primarily found in host-associated habitats, indicating its dependency on specific hosts for survival and replication. The strain is mesophilic, with an optimal growth temperature of 37°C, which aligns with the average human body temperature, facilitating its association with Homo sapiens and other hosts including Gallus gallus (chickens), various Aves, primates, and several mammalian species. This strain has a single replicon and is composed of two membranes, characteristic of its gram-negative classification. Its biotic relationship is categorized as free-living, suggesting it can exist independently within its host environment, yet it is primarily pathogenic in humans. The health effects associated with Helicobacter pylori strain 2029 include a range of gastrointestinal diseases such as chronic gastric inflammation, peptic ulcers, and various forms of gastric cancer, including adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Given its significant role in chronic gastric conditions, the presence of Helicobacter pylori strain 2029 in human populations poses a substantial public health concern. Its association with serious diseases underscores the importance of understanding its pathogenic mechanisms and interactions within the gastrointestinal tract. This insight into its pathogenicity and health impacts can inform strategies for prevention and treatment of related gastrointestinal diseases.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain 2029

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain 2029
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain 2029 contig_9, whole genome shotgun

Gene Summary

Adenine Count

504008 bp

Thymine Count

503517 bp

Guanine Count

323517 bp

Cytosine Count

318225 bp

Genome Length

1649365 bp

Protein-coding Genes

1478 genes

Non-Coding Genes

42 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
ump kinaseBB465_06310Not AvailableNegative1076934 - 107765626174.0
menaquinone biosynthesis proteinBB465_06315Not AvailableNegative1077766 - 107844926635.8
bifunctional aconitate hydratase 2/2-methylisocitrate dehydrataseBB465_06320Not AvailablePositive1078579 - 108113792683.8
hypothetical proteinBB465_06325Not AvailablePositive1081214 - 108148010186.5
hypothetical proteinBB465_06330Not AvailablePositive1081740 - 108302949401.9
hypothetical proteinBB465_06335Not AvailablePositive1083122 - 108448951868.6
hypothetical proteinBB465_06340Not AvailableNegative1084496 - 108502320040.9
Tmrna,resume consensus sequence (at 77): aataactgtaaacaacgcNot AvailableNot AvailablePositive1085066 - 1085451Not Available
outer-membrane lipoprotein carrier proteinBB465_06350Not AvailableNegative1085509 - 108606321230.1
preprotein translocase subunit secaBB465_06355Not AvailablePositive1086210 - 108880799051.1

Displaying genes 1001 – 1010 of 1520 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total