Helicobacter pylori strain 2020

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain 2020 is a Gram-negative, microaerophilic bacterium characterized by its spirilla shape and single-cell arrangement. It possesses flagella, which facilitate its motility, although it is noted that it does not exhibit mobility. This strain is mesophilic, with an optimal growth temperature of 37°C, and is associated with various hosts, including Homo sapiens, Gallus gallus, Aves, Primates, Mammalia, Amoeba, Rodentia, Cricetinae, and Thais. The strain is known for its biotic relationship as free-living in the gastrointestinal tract of its hosts. It has been linked to numerous health effects, primarily related to chronic gastric conditions. These include chronic gastric inflammation, gastric ulcers, and a range of cancers such as gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Other associated health issues include gastroesophageal reflux disease (GERD) and functional dyspepsia. The bacterium's pathogenicity in humans is particularly concerning, as it contributes to various gastrointestinal diseases and conditions, including atrophic gastritis and dysplasia. An ecological insight into Helicobacter pylori strain 2020 reveals its significant role in the human microbiome, particularly in the stomach environment. Its presence can lead to both asymptomatic inflammatory responses and severe gastrointestinal diseases, highlighting its dual nature as both a common inhabitant of the human gut and a potential pathogen. Understanding the dynamics of this strain is crucial for addressing the health implications associated with its infection.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain 2020

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain 2020
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain 2020 scaffold_99, whole genome shotgun

Gene Summary

Adenine Count

528778 bp

Thymine Count

522028 bp

Guanine Count

336871 bp

Cytosine Count

332041 bp

Genome Length

1719718 bp

Protein-coding Genes

1495 genes

Non-Coding Genes

44 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
formyltetrahydrofolate deformylaseBB469_07865Not AvailablePositive1197847 - 119872833605.3
restriction endonuclease subunit sBB469_07870Not AvailablePositive1198770 - 119925018415.2
pyruvate kinaseBB469_07890Not AvailablePositive1203769 - 120427219340.3
ribonuclease nBB469_07895Not AvailableNegative1204955 - 120583334621.9
biotin synthase biobBB469_07900Not AvailableNegative1205833 - 120668131463.8
trna preq1(34) s-adenosylmethionine ribosyltransferase-isomerase queaBB469_02430Not AvailableNegative1207515 - 120855239902.4
twin arginine-targeting protein translocase tatcBB469_02435Not AvailableNegative1208553 - 120928727251.0
twin arginine-targeting protein translocase tatbBB469_02440Not AvailableNegative1209280 - 120976218324.7
holliday junction dna helicase ruvbBB469_02445Not AvailableNegative1209830 - 121084037228.4
3-methyl-2-oxobutanoate hydroxymethyltransferaseBB469_02450Not AvailableNegative1210841 - 121165329866.5

Displaying genes 1101 – 1110 of 1539 in total

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total