Helicobacter pylori strain 2040

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain 2040 is a Gram-negative bacterium characterized as a microaerophilic spirilla. This organism is notable for its ability to inhabit various hosts, including Homo sapiens, Gallus gallus, Aves, Primates, Mammalia, Amoeba, Rodentia, and Cricetinae. It exists as single cells and possesses flagella, which facilitate its mobility in host environments. The bacterium has an optimal growth temperature of 37 degrees Celsius and is classified as mesophilic, thriving within a temperature range that supports its biological functions. Strain 2040 is associated with several significant health effects, primarily linked to gastric conditions. It is recognized for its role in chronic gastric inflammation, and it is a contributing factor to more severe gastrointestinal diseases, including gastric cancer, gastric ulcers, and mucosa-associated lymphoid tissue lymphoma. The presence of this bacterium can lead to various forms of dyspepsia and peptic ulcer disease, underscoring its pathogenicity in humans. The bacterium's biotic relationship is classified as free-living, indicating its adaptability to diverse ecological niches within host organisms. With a single replicon and two membranes, H. pylori strain 2040 demonstrates a complex cellular structure that allows it to thrive in the host-associated habitat. The ecological insight drawn from these traits emphasizes the significance of H. pylori in the gastrointestinal microbiome, where it plays a dual role as both a commensal organism and a pathogenic agent, influencing health outcomes in its diverse array of hosts.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain 2040

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain 2040
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain 2040 scaffold_90, whole genome shotgun

Gene Summary

Adenine Count

509093 bp

Thymine Count

510486 bp

Guanine Count

319938 bp

Cytosine Count

326821 bp

Genome Length

1666338 bp

Protein-coding Genes

1474 genes

Non-Coding Genes

43 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
peptide abc transporter permeaseBB463_00095Not AvailableNegative15132 - 1613636975.4
peptide abc transporter substrate-binding proteinBB463_00100Not AvailableNegative16147 - 1779662392.9
50s ribosomal protein l27BB463_00105Not AvailableNegative17913 - 181799778.76
5s ribosomal rnaNot AvailableNot AvailablePositive18459 - 18577Not Available
50s ribosomal protein l21BB463_00110Not AvailableNegative18194 - 1850811851.8
flagellar biosynthesis protein flglBB463_00115Not AvailablePositive18751 - 2123792002.0
acylamide amidohydrolaseBB463_00120Not AvailableNegative21318 - 2233737696.0
bifunctional aminodeoxychorismate synthase component i/aminotransferaseBB463_00125Not AvailableNegative22483 - 2416865021.2
hypothetical proteinBB463_00130Not AvailableNegative24169 - 2504133967.6
chorismate mutaseBB463_00135Not AvailableNegative25054 - 2534411345.8

Displaying genes 21 – 30 of 1517 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total