Helicobacter pylori strain 2040

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain 2040 is a Gram-negative bacterium characterized as a microaerophilic spirilla. This organism is notable for its ability to inhabit various hosts, including Homo sapiens, Gallus gallus, Aves, Primates, Mammalia, Amoeba, Rodentia, and Cricetinae. It exists as single cells and possesses flagella, which facilitate its mobility in host environments. The bacterium has an optimal growth temperature of 37 degrees Celsius and is classified as mesophilic, thriving within a temperature range that supports its biological functions. Strain 2040 is associated with several significant health effects, primarily linked to gastric conditions. It is recognized for its role in chronic gastric inflammation, and it is a contributing factor to more severe gastrointestinal diseases, including gastric cancer, gastric ulcers, and mucosa-associated lymphoid tissue lymphoma. The presence of this bacterium can lead to various forms of dyspepsia and peptic ulcer disease, underscoring its pathogenicity in humans. The bacterium's biotic relationship is classified as free-living, indicating its adaptability to diverse ecological niches within host organisms. With a single replicon and two membranes, H. pylori strain 2040 demonstrates a complex cellular structure that allows it to thrive in the host-associated habitat. The ecological insight drawn from these traits emphasizes the significance of H. pylori in the gastrointestinal microbiome, where it plays a dual role as both a commensal organism and a pathogenic agent, influencing health outcomes in its diverse array of hosts.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain 2040

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain 2040
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain 2040 scaffold_90, whole genome shotgun

Gene Summary

Adenine Count

509093 bp

Thymine Count

510486 bp

Guanine Count

319938 bp

Cytosine Count

326821 bp

Genome Length

1666338 bp

Protein-coding Genes

1474 genes

Non-Coding Genes

43 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinBB463_02195Not AvailableNegative1320419 - 13206348691.05
tat pathway signal proteinBB463_02200Not AvailableNegative1320718 - 132159332716.9
catalaseBB463_02205Not AvailableNegative1321738 - 132325558612.1
hypothetical proteinBB463_02210Not AvailablePositive1323572 - 132594788516.2
crossover junction endodeoxyribonuclease ruvcBB463_02215Not AvailableNegative1325948 - 132642117453.5
nucleaseBB463_02220Not AvailablePositive1326553 - 132728428444.0
hypothetical proteinBB463_02225Not AvailableNegative1327979 - 13281827552.46
holliday junction dna helicase ruvaBB463_02235Not AvailableNegative1329502 - 133005320198.1
hypothetical proteinBB463_02240Not AvailableNegative1330079 - 133192370994.1
murein biosynthesis integral membrane protein murjBB463_02245Not AvailablePositive1332016 - 133347654526.8

Displaying genes 1211 – 1220 of 1517 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total