Helicobacter pylori strain 22317

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain 22317 is a Gram-negative bacterium characterized by its spirilla shape and microaerophilic oxygen requirement. It is distinguished by its single-cell arrangement and the presence of flagella, which contribute to its motility. This strain is mesophilic, with an optimal growth temperature of 37°C. H. pylori strain 22317 is associated with various hosts, including Homo sapiens (humans), Gallus gallus (chickens), Aves (birds), primates, and several mammalian and rodent species. Its biotic relationship is classified as free-living, indicating that it can survive independently within its host-associated habitats. The bacterium is known for its significant health effects, which include a wide range of gastrointestinal diseases. These effects encompass chronic gastric inflammation, gastric ulcers, and various forms of cancer, such as gastric carcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Specifically, it is implicated in conditions like peptic ulcer disease, chronic gastritis, and dyspepsia, reflecting its role in both symptomatic and asymptomatic mucosal inflammatory responses. Interestingly, H. pylori strain 22317 highlights the complex interplay between microbial pathogens and host health, illustrating how a single bacterial strain can lead to diverse health outcomes in different host species. The strain's pathogenicity in humans underscores its relevance in clinical microbiology and public health, as it poses a risk for serious gastrointestinal diseases. Understanding its characteristics and effects can enhance our knowledge of its role in human health and disease.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strainstrain 22317

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori strain 22317
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain 22317 scaffold_9, whole genome shotgun

Gene Summary

Adenine Count

505635 bp

Thymine Count

507013 bp

Guanine Count

323054 bp

Cytosine Count

322418 bp

Genome Length

1658120 bp

Protein-coding Genes

1470 genes

Non-Coding Genes

44 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
nucleoside transporter nupcBB423_00845Not AvailablePositive153730 - 15498643795.2
phosphopentomutaseBB423_00850Not AvailablePositive154998 - 15623346001.0
purine-nucleoside phosphorylaseBB423_00855Not AvailablePositive156236 - 15693725789.6
hypothetical proteinBB423_00860Not AvailablePositive157397 - 15932569848.0
guanine permeaseBB423_00865Not AvailablePositive159792 - 16109946737.2
glucose/galactose mfs transporterBB423_00870Not AvailablePositive161228 - 16245143828.7
hypothetical proteinBB423_00875Not AvailableNegative162669 - 16322020616.0
glutamine abc transporter substrate-binding proteinBB423_00880Not AvailableNegative163337 - 16417031264.0
glutamine abc transporter atp-binding proteinBB423_00885Not AvailableNegative164220 - 16496628037.4
amino acid abc transporter permeaseBB423_00890Not AvailableNegative164968 - 16563924851.5

Displaying genes 171 – 180 of 1514 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total