Helicobacter pylori strain YN4-84

Helicobacter pylori strain YN4-84 is a Gram-negative, microaerophilic bacterium characterized by its spirilla shape and presence of flagella, which contributes to its mobility. This strain is host-associated, primarily found within the gastrointestinal tracts of various hosts, including Homo sapiens, Gallus gallus, and other mammals and birds. The optimal growth temperature for H. pylori YN4-84 is 37°C, classifying it as mesophilic. H. pylori strain YN4-84 has a unique biotic relationship; while it is free-living, it is also pathogenic to humans, leading to numerous health complications. The strain is associated with chronic gastric inflammation, peptic ulcer disease, and several forms of gastric cancer, including gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. It can also cause conditions such as GERD and functional dyspepsia, demonstrating its significant impact on gastrointestinal health. The strain possesses one replicon and has a double membrane structure, which is typical for Gram-negative bacteria. The diverse range of hosts indicates its adaptability and potential ecological significance within various environments, particularly in relation to human health and disease. Understanding the pathogenicity and health effects associated with H. pylori strain YN4-84 is essential for developing therapeutic strategies and public health interventions to manage the gastrointestinal diseases linked to this organism.