Arcanobacterium haemolyticum DSM 20595

Gram-positiveRodNon-motileFacultative anaerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Actinomycetales

Family

Actinomycetaceae

Genus

Arcanobacterium

Description

Arcanobacterium haemolyticum DSM 20595 is a gram-positive, rod-shaped bacterium that prefers mesophilic temperatures (optimal growth at around 30–37°C). Classified as a chemoheterotroph, this organism derives its energy and carbon from organic matter, making it reliant on the consumption of existing biomass. It is also categorized as a facultative anaerobe, capable of functioning in both aerobic and anaerobic environments. This microbe is often found in various body sites, particularly in human skin, throat, and respiratory tract. Its presence is notable as it can be part of the normal microbiota; however, it has been implicated in opportunistic infections, especially in immunocompromised individuals. The ability to thrive in different environments underscores its adaptability and importance in clinical microbiology. Arcanobacterium haemolyticum is noteworthy for its hemolytic activity, which can lead to lysis of red blood cells. This characteristic is especially significant in laboratory identification, as it can be detected through hemolysis on blood agar. The organism has been associated with pharyngitis and skin infections, particularly in adolescents and young adults, leading to confusion with streptococcal infections. The ability of A. haemolyticum to produce specific virulence factors, including toxins, also contributes to its pathogenic potential. Research has indicated that the bacterium may have a role in contributing to inflammatory responses, which could further complicate infections in susceptible populations. Additionally, its increasing recognition as a pathogen highlights the need for heightened awareness in clinical settings to ensure appropriate diagnosis and treatment.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderActinomycetales
FamilyActinomycetaceae
GenusArcanobacterium
SpeciesArcanobacterium haemolyticum
StrainDSM 20595

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Arcanobacterium haemolyticum DSM 20595
AI-generated image based on bacteria physiology
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipSymbiotic
Host(s)Not Available
Cell arrangementChains; Pairs; Singles
SporulationNonsporulating
Energy sourceChemoorganotroph
PathogenicityYes

Genome Summary

Arcanobacterium haemolyticum DSM 20595, complete sequence.

Gene Summary

Adenine Count

469430 bp

Thymine Count

461416 bp

Guanine Count

523391 bp

Cytosine Count

531917 bp

Genome Length

1986154 bp

Protein-coding Genes

1791 genes

Non-Coding Genes

76 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
phosphotransferase enzyme family proteinARCH_RS00070Not AvailableNegative18755 - 1984640488.9
1,3-beta-galactosyl-n-acetylhexosamine phosphorylaseARCH_RS00075Not AvailableNegative19831 - 2198781347.9
rok family transcriptional regulatorARCH_RS00080Not AvailablePositive22246 - 2341841595.8
sodium/glutamate symporterARCH_RS00085Not AvailableNegative23405 - 2464044260.9
gnat family n-acetyltransferaseARCH_RS09160Not AvailablePositive24767 - 2537222852.4
tetr/acrr family transcriptional regulatorARCH_RS00095Not AvailableNegative25350 - 2605726096.4
yhge/pip domain-containing proteinARCH_RS00100Not AvailablePositive26177 - 29101100446.0
l-lactate permeaseARCH_RS00105Not AvailablePositive29323 - 3097556951.9
(fe-s)-binding proteinARCH_RS00110Not AvailablePositive31039 - 3182728199.0
lutb/lldf family l-lactate oxidation iron-sulfur proteinARCH_RS00115Not AvailablePositive31827 - 3335356434.4

Displaying genes 41 – 50 of 1867 in total

Metabolites

296 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001111keto-D-tagaturonateC6H9O7Chemical structure of keto-D-tagaturonateNot available
Average193.132Da
Monoisotopic193.0353762Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001639CobinamideC48H72CoN11O8Chemical structure of Cobinamide13497-85-3
Average990.0874Da
Monoisotopic989.4897335Da
BASm0001661Cu(2+)CuChemical structure of Cu(2+)7440-50-8
Average63.546Da
Monoisotopic62.929601079Da
BASm0001921(S)-3-methyl-2-oxopentanoateC6H9O3Chemical structure of (S)-3-methyl-2-oxopentanoate1460-34-0
Average129.1339Da
Monoisotopic129.0551692Da
BASm0002197D-arabinoseC5H10O5Chemical structure of D-arabinoseNot available
Average150.1299Da
Monoisotopic150.05282343Da

Displaying 1–10 of 296 metabolites

Health Effects

No health effects information available for this bacterium.