Burkholderia mallei NCTC 10229

Gram-negativeRodNon-motileAerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Betaproteobacteria

Order

Burkholderiales

Family

Burkholderiaceae

Genus

Burkholderia

Description

Burkholderia mallei is the etiologic agent of glanders, a disease that is often fatal. Its natural reservoir are horses and other equines, but it can be occasionally transmitted to humans either by inhalation or through breaks in the skin. It is an obligate animal pathogen, with an intracellular localization. B. mallei is highly infectious as an aerosol and was used as a biological weapon in the American Civil War and in both World Wars. Unlike the related bacterium B.pseudomallei it is non-motile. One of its virulence factors has been identified as the type III secretion system, another as the newly characterized type VI (T6S). Strain NCTC 10229 will be used for comparative genomics. (EBI Integr8)

Taxonomy

Kingdom	Pseudomonadati
Phylum	Pseudomonadota
Class	Betaproteobacteria
Order	Burkholderiales
Family	Burkholderiaceae
Genus	Burkholderia
Species	Burkholderia mallei
Strain	NCTC 10229

Profile

Physiology
Gram staining properties	Negative
Shape	Rod
Mobility	No
Flagellar presence	Yes
Number of membranes	2

Image source: Wikipedia/Wikimedia

Ecology, Host, and Life Cycle
Oxygen requirements	Aerobe
Optimal temperature	Not Available
Temperature range	Mesophilic
Habitat	HostAssociated
Biotic relationship	Free living
Host(s)	Not Available
Cell arrangement	Not Available
Sporulation	Not Available
Energy source	Not Available
Pathogenicity	Yes

Genome Summary

Burkholderia mallei NCTC 10229 chromosome II, complete sequence.

NC_008835.1 NC_008836.1

Gene Summary

Adenine Count

355315 bp

Thymine Count

354120 bp

Guanine Count

788156 bp

Cytosine Count

786504 bp

Genome Length

2284095 bp

Protein-coding Genes

1964 genes

Non-Coding Genes

15 genes

# of Chromosomes/Plasmids

Genes

Name	Locus Tag	UniProt ID	Strand Orientation	Gene Start/End	Protein Molecular Weight
carboxylating nicotinate-nucleotide diphosphorylase	BMA10229_RS14370	Not Available	Negative	1038697 - 1039581	31565.7
quinolinate synthase nada	BMA10229_RS14375	Not Available	Negative	1039578 - 1040714	40830.1
acyl-coa desaturase	BMA10229_RS14380	Not Available	Negative	1040883 - 1042079	46198.0
mechanosensitive ion channel family protein	BMA10229_RS14385	Not Available	Negative	1042276 - 1043628	48363.8
rsmb/nop family class i sam-dependent rna methyltransferase	BMA10229_RS14390	Not Available	Negative	1043640 - 1044902	45472.2
phosphoribosylglycinamide formyltransferase	BMA10229_RS14395	Not Available	Negative	1044899 - 1045561	23208.8
bifunctional riboflavin kinase/fad synthetase	BMA10229_RS14400	Not Available	Positive	1045686 - 1046678	35669.7
isoleucine--trna ligase	BMA10229_RS14405	Not Available	Positive	1046790 - 1049627	105685.0
signal peptidase ii	BMA10229_RS14410	Not Available	Positive	1049627 - 1050127	18100.4
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase coabc	BMA10229_RS14415	Not Available	Positive	1050189 - 1051400	43182.2

Displaying genes 2941 – 2950 of 5205 in total

Pathways

1327 pathways

2,3-Dihydroxybenzoate Biosynthesis

Biosynthesis of Siderophore Group Nonribosomal Peptides

Lysine Biosynthesis

Taurine Metabolism

Glycolysis and Pyruvate Dehydrogenase

Arginine Metabolism

Ornithine Metabolism

Proline Metabolism

Show All 1327 Pathways

Metabolite ID	Metabolite name	CAS number	Average mass Monoisotopic mass
BASm0000250	2,5-didehydro-D-gluconateC6H7O7	`53736-12-2`	Average191.1156Da Monoisotopic191.019177578Da
BASm0000253	2-oxopent-4-enoateC5H5O3	Not available	Average113.093Da Monoisotopic113.024417601Da
BASm0000260	3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5	Not available	Average405.556Da Monoisotopic405.264647871Da
BASm0000428	3-oxoadipateC6H6O5	Not available	Average158.11Da Monoisotopic158.022620453Da
BASm0000516	6-deoxyerythronolide BC21H38O6	Not available	Average386.5228Da Monoisotopic386.2668389Da
BASm0000553	biphenyl-2,3-diolC12H10O2	Not available	Average186.2066Da Monoisotopic186.0680796Da
BASm0000592	(S)-1-phenylethanolC8H10O	Not available	Average122.1644Da Monoisotopic122.0731649Da
BASm0000893	crotonobetaineC7H13NO2	`927-89-9`	Average143.1836Da Monoisotopic143.0946287Da
BASm0000989	GlycerolC3H8O3	`56-81-5`	Average92.0938Da Monoisotopic92.04734412Da
BASm0001003	phthalateC8H4O4	Not available	Average164.117Da Monoisotopic164.0120558Da

Displaying 1–10 of 1753 metabolites

Health Effects

No health effects information available for this bacterium.