Burkholderia mallei NCTC 10229

Gram-negativeRodNon-motileAerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Betaproteobacteria

Order

Burkholderiales

Family

Burkholderiaceae

Genus

Burkholderia

Description

Burkholderia mallei is the etiologic agent of glanders, a disease that is often fatal. Its natural reservoir are horses and other equines, but it can be occasionally transmitted to humans either by inhalation or through breaks in the skin. It is an obligate animal pathogen, with an intracellular localization. B. mallei is highly infectious as an aerosol and was used as a biological weapon in the American Civil War and in both World Wars. Unlike the related bacterium B.pseudomallei it is non-motile. One of its virulence factors has been identified as the type III secretion system, another as the newly characterized type VI (T6S). Strain NCTC 10229 will be used for comparative genomics. (EBI Integr8)

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassBetaproteobacteria
OrderBurkholderiales
FamilyBurkholderiaceae
GenusBurkholderia
SpeciesBurkholderia mallei
StrainNCTC 10229

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Burkholderia mallei NCTC 10229
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Burkholderia mallei NCTC 10229 chromosome II, complete sequence.

Gene Summary

Adenine Count

355315 bp

Thymine Count

354120 bp

Guanine Count

788156 bp

Cytosine Count

786504 bp

Genome Length

2284095 bp

Protein-coding Genes

1964 genes

Non-Coding Genes

15 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
type iii secretion system needle filament protein bsalBMA10229_RS08905Not AvailableNegative2108219 - 21084889924.57
prgh/eprh family type iii secretion apparatus proteinBMA10229_RS08910Not AvailableNegative2108485 - 210977146324.9
t3ss3/t6ss1 transcriptional regulator bsanBMA10229_RS08915Not AvailablePositive2110282 - 211092323635.5
sctc family type iii secretion system outer membrane ring subunit bsaoBMA10229_RS08920Not AvailablePositive2110937 - 211281466573.9
sctw family type iii secretion system gatekeeper subunit bsapBMA10229_RS08925Not AvailablePositive2112811 - 211393240415.0
sctv family type iii secretion system export apparatus subunit bsaqBMA10229_RS08930Not AvailablePositive2113968 - 211604074421.3
type iii secretion system protein bsarBMA10229_RS08935Not AvailablePositive2116052 - 211645914838.8
sctn family type iii secretion system atpase bsasBMA10229_RS08940Not AvailablePositive2116456 - 211776646901.1
type iii secretion system protein bsatBMA10229_RS08945Not AvailablePositive2117763 - 211822717483.9
t3ss secretion apparatus bsauBMA10229_RS08950Not AvailablePositive2118205 - 211945242283.3

Displaying genes 1831 – 1840 of 5205 in total

Metabolites

1753 records
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Result columns

Structure search compares stored SMILES, InChI, and InChIKey text. Exact mass must match the stored database value.

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Metabolite IDMetabolite nameStructureCAS number
Average massMonoisotopic mass
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00004283-oxoadipateC6H6O5Chemical structure of 3-oxoadipateNot available
Average158.11Da
Monoisotopic158.022620453Da
BASm00005166-deoxyerythronolide BC21H38O6Chemical structure of 6-deoxyerythronolide BNot available
Average386.5228Da
Monoisotopic386.2668389Da
BASm0000553biphenyl-2,3-diolC12H10O2Chemical structure of biphenyl-2,3-diolNot available
Average186.2066Da
Monoisotopic186.0680796Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000893crotonobetaineC7H13NO2Chemical structure of crotonobetaine927-89-9
Average143.1836Da
Monoisotopic143.0946287Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001003phthalateC8H4O4Chemical structure of phthalateNot available
Average164.117Da
Monoisotopic164.0120558Da

Displaying 1–10 of 1753 metabolites

Health Effects

No health effects information available for this bacterium.