Granulibacter bethesdensis CGDNIH1

Acetobacteraceae are alphaproteobacteria including the acetic acid bacteria, which incompletely oxidize carbohydrates and alcohols, leading to production of vinegar among other chemicals. They are found worldwide on plant material.G.bethesdensis is a non-motile Gram-negative rod able to growth on methanol as its sole carbon source, and encodes the enzymes necessary for conversion of alcohols to acetic acid making it both an acetic acid bacterium and a methylotroph. Strain CGDNIH1 was identified in excised lymph nodes from a 39 year old male patient with chronic granulomatous disease (CGD), a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections with Staphylococcus aureus, Serratia marcescens, Burkholderia cepacia complex Nocardia and Aspergillus species, and now Granulibacter bethesdensis. This is the first reported case of invasive human disease caused by any of the Acetobacteraceae. It is surrounded by a capsule, which might confer increased resistance. (HAMAP: GRABC)