Clostridium novyi NT

Gram-positiveRodMotileAnaerobe

Kingdom

Bacillati

Phylum

Bacillota

Class

Clostridia

Order

Eubacteriales

Family

Clostridiaceae

Genus

Clostridium

Description

Clostridium novyi-NT, a Gram +, spore-forming bacteria, is an experimentally developed attenuated strain of pathogenic C.novyi. To do so, the major systemic toxin gene-containing episome has been deleted. It was created to be used as an bacteriolytic anti-tumor agent. An anaerobic bacterium is ideally suited as an anti-tumor agent as the only hypoxic regions within mammals are tumors. Intravenous injection of C.novyi-NT spores in rabbits and mice has produced anti-tumor effects without excessive toxicity. While the spores are very stable, the vegetative form is very sensitive to oxygen. (EBI Integr8)

Taxonomy

KingdomBacillati
PhylumBacillota
ClassClostridia
OrderEubacteriales
FamilyClostridiaceae
GenusClostridium
SpeciesClostridium novyi
StrainNT

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityYes
Flagellar presenceNot Available
Number of membranes1
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatTerrestrial
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementPairs - Singles
SporulationSporulating
Energy sourceChemoorganotroph
PathogenicityNo

Genome Summary

Clostridium novyi NT, complete sequence.

Gene Summary

Adenine Count

911949 bp

Thymine Count

900609 bp

Guanine Count

369148 bp

Cytosine Count

366014 bp

Genome Length

2547720 bp

Protein-coding Genes

2272 genes

Non-Coding Genes

167 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
uroporphyrinogen-iii c-methyltransferaseNT01CX_RS08970Not AvailableNegative1935693 - 193718655613.4
hydroxymethylbilane synthaseNT01CX_RS08975Not AvailableNegative1937188 - 193809033922.4
bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelataseNT01CX_RS08980Not AvailableNegative1938130 - 193872622982.0
glutamyl-trna reductaseNT01CX_RS08985Not AvailableNegative1938741 - 193997647554.9
4fe-4s binding proteinNT01CX_RS08990Not AvailableNegative1940089 - 194100334777.5
na+/h+ antiporter family proteinNT01CX_RS08995Not AvailableNegative1941256 - 194256045986.4
staygreen family proteinNT01CX_RS09000Not AvailablePositive1942804 - 194325617642.8
is1182-like element iscno1 family transposaseNT01CX_RS09005Not AvailableNegative1943526 - 194496556509.2
prephenate dehydratase domain-containing proteinNT01CX_RS12485Not AvailablePositive1945208 - 194559114691.7
act domain-containing proteinNT01CX_RS12490Not AvailablePositive1945599 - 194603316441.1

Displaying genes 1851 – 1860 of 2439 in total

Metabolites

121 records
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Mass search
Result columns

Structure search compares stored SMILES, InChI, and InChIKey text. Exact mass must match the stored database value.

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Metabolite IDMetabolite nameStructureCAS number
Average massMonoisotopic mass
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0001717fumarateC4H2O4Chemical structure of fumarateNot available
Average114.0563Da
Monoisotopic113.9953086Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0001921(S)-3-methyl-2-oxopentanoateC6H9O3Chemical structure of (S)-3-methyl-2-oxopentanoate1460-34-0
Average129.1339Da
Monoisotopic129.0551692Da
BASm00021577-cyano-7-deazaguanineC7H5N5OChemical structure of 7-cyano-7-deazaguanineNot available
Average175.1475Da
Monoisotopic175.0494098Da
BASm0002198beta-D-ribofuranoseC5H10O5Chemical structure of beta-D-ribofuranose50-69-1
Average150.1299Da
Monoisotopic150.05282343Da
BASm0002305(S)-2-ethyl-2-hydroxy-3-oxobutanoateC6H9O4Chemical structure of (S)-2-ethyl-2-hydroxy-3-oxobutanoateNot available
Average145.135Da
Monoisotopic145.0506324Da

Displaying 1–10 of 121 metabolites

Health Effects

No health effects information available for this bacterium.