Campylobacter concisus 13826

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Campylobacteraceae

Genus

Campylobacter

Description

Campylobacter concisus 13826 is a gram-negative, curved bacillus that thrives optimally at moderate temperatures, classifying it as a mesophile. This microbe is a chemoheterotroph, relying on organic compounds for energy and carbon, and exhibits microaerophilic behavior, meaning it requires lower levels of oxygen than what is present in the atmosphere for optimal growth. Campylobacter concisus is primarily associated with the human gastrointestinal tract, where it can be found in the oral cavity and intestines, but has also been identified in other body sites, including the respiratory tract and genitourinary system. The gram-negative nature of Campylobacter concisus is indicative of its double membrane structure, featuring an outer membrane composed of lipopolysaccharides, which can help evade the host immune response. Its curved bacillus shape enhances motility, allowing this microorganism to navigate through viscous environments like intestinal mucus. As a mesophile, it thrives at temperatures around 37°C, typical of the human body, which supports its role as a pathogen. The chemoheterotrophic lifestyle of Campylobacter concisus relies on carbohydrates and amino acids for energy, underscoring its adaptability to the nutrient-rich environments of the human gut. Its microaerophilic requirement highlights its unique metabolic adaptations, allowing it to flourish in low-oxygen environments while potentially competing with other gut flora. Campylobacter concisus has garnered attention for its association with gastrointestinal diseases, particularly inflammatory bowel disease. Emerging research suggests that dysbiosis involving this microbe may play a role in gut health and disease progression, paving the way for further studies into its pathogenic mechanisms and potential therapeutic targets. Its ability to persist in various human body sites and adapt to different environments underscores its significance in microbial ecology and human health.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyCampylobacteraceae
GenusCampylobacter
SpeciesCampylobacter concisus
Strain13826

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Campylobacter concisus 13826
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementChains - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Campylobacter concisus 13826 plasmid pCCON16, complete sequence.

Gene Summary

Adenine Count

5880 bp

Thymine Count

5071 bp

Guanine Count

2844 bp

Cytosine Count

2662 bp

Genome Length

16457 bp

Protein-coding Genes

23 genes

Non-Coding Genes

0 genes

# of Chromosomes/Plasmids

3

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinCCC13826_RS11065Not AvailablePositive14170 - 142985076.22
plasmid mobilization proteinCCC13826_RS10555Not AvailablePositive14285 - 1460211915.4
relaxase/mobilization nuclease domain-containing proteinCCC13826_RS10560Not AvailablePositive14592 - 1645772449.7
chromosomal replication initiator protein dnaaCCC13826_RS00005Not AvailablePositive1 - 131149921.7
dna polymerase iii subunit betaCCC13826_RS00010Not AvailablePositive1465 - 253240821.4
dna topoisomerase (atp-hydrolyzing) subunit bCCC13826_RS00015Not AvailablePositive2550 - 485986330.2
preq(1) synthaseCCC13826_RS00020Not AvailablePositive4878 - 547423374.0
hd domain-containing proteinCCC13826_RS00025Not AvailablePositive5474 - 670948202.1
Ncrna_class:srp_rnaNot AvailableNot AvailablePositive6696 - 6793Not Available
hypothetical proteinCCC13826_RS00035Not AvailablePositive6907 - 734117233.8

Displaying genes 21 – 30 of 2133 in total

Metabolites

1849 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001035indole-3-pyruvateC11H8NO3Chemical structure of indole-3-pyruvate35656-49-6
Average202.1861Da
Monoisotopic202.0504181Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da

Displaying 1–10 of 1849 metabolites

Health Effects

No health effects information available for this bacterium.