Campylobacter lari RM2100

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Campylobacteraceae

Genus

Campylobacter

Description

Campylobacter lari RM2100 is a gram-negative, spiral-shaped bacterium characterized as a microaerophile and a chemoheterotroph, which thrives optimally at temperatures around 42°C. This microorganism is commonly found in various body sites of different species, particularly in the intestines of birds, mammals, and reptiles, where it plays a role in the gut microbiome. As a gram-negative organism, C. lari possesses a thin peptidoglycan layer surrounded by an outer membrane containing lipopolysaccharides, giving it distinctive staining properties. Its spiral shape and motility, facilitated by a single polar flagellum, enable it to navigate the viscous environments of intestinal tracts, contributing to its virulence mechanisms. Microaerophilic in nature, C. lari requires reduced levels of oxygen for optimal growth, making it particularly well-suited to the anaerobic conditions found within the intestines. This oxygen dependency is crucial for its metabolic processes, as it relies on the fermentation of organic compounds as a primary energy source, classifying it as a chemoheterotroph. Notably, C. lari has been associated with gastrointestinal illnesses in humans, particularly through the consumption of contaminated water or undercooked poultry. Its pathogenic potential is underlined by its ability to evade the host immune response and adhere to intestinal epithelial cells, leading to inflammation and infection. Moreover, this microbe has garnered attention in research for its unique genetic and biochemical properties, which may offer insights into the broader Campylobacter genus, paving the way for novel therapeutic approaches to combat Campylobacter-related infections. The study of C. lari RM2100 emphasizes the importance of understanding microbial adaptation and survival strategies within diverse ecological niches.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyCampylobacteraceae
GenusCampylobacter
SpeciesCampylobacter lari
StrainRM2100

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Campylobacter lari RM2100
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperatureNot Available
Temperature rangeMesophilic
HabitatMultiple
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementChains - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityYes

Genome Summary

Campylobacter lari RM2100, complete sequence.

Gene Summary

Adenine Count

537198 bp

Thymine Count

535147 bp

Guanine Count

226867 bp

Cytosine Count

226248 bp

Genome Length

1525460 bp

Protein-coding Genes

1537 genes

Non-Coding Genes

58 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
arsc/spx/mgsr family proteinCLA_RS04930Not AvailableNegative946992 - 94731812636.5
class ii 3-deoxy-7-phosphoheptulonate synthaseCLA_RS04935Not AvailableNegative947315 - 94865550323.6
cupin domain-containing proteinCLA_RS04940Not AvailableNegative948708 - 94906113446.4
50s ribosomal protein l19CLA_RS04945Not AvailableNegative949064 - 94942013809.9
trna (guanosine(37)-n1)-methyltransferase trmdCLA_RS04950Not AvailableNegative949432 - 95013626931.5
ribosome maturation factor rimmCLA_RS04955Not AvailableNegative950133 - 95065720030.3
kh domain-containing proteinCLA_RS04960Not AvailableNegative950647 - 9508929292.34
30s ribosomal protein s16CLA_RS04965Not AvailableNegative950895 - 9511228753.73
signal recognition particle proteinCLA_RS04970Not AvailableNegative951194 - 95253149090.1
pseudouridine synthase family proteinCLA_RS04975Not AvailableNegative952595 - 95334728630.1

Displaying genes 1001 – 1010 of 1639 in total

Metabolites

1707 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000592(S)-1-phenylethanolC8H10OChemical structure of (S)-1-phenylethanolNot available
Average122.1644Da
Monoisotopic122.0731649Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001035indole-3-pyruvateC11H8NO3Chemical structure of indole-3-pyruvate35656-49-6
Average202.1861Da
Monoisotopic202.0504181Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm0001639CobinamideC48H72CoN11O8Chemical structure of Cobinamide13497-85-3
Average990.0874Da
Monoisotopic989.4897335Da

Displaying 1–10 of 1707 metabolites

Health Effects

No health effects information available for this bacterium.