Akkermansia muciniphila str. CBA5201

Gram-negativeCocciNon-motileAnaerobe

Kingdom

Pseudomonadati

Phylum

Verrucomicrobiota

Class

Verrucomicrobiia

Order

Verrucomicrobiales

Family

Akkermansiaceae

Genus

Akkermansia

Description

Akkermansia muciniphila str. CBA5201 is a Gram-negative, anaerobic bacterium characterized by its cocci shape, which typically arranges in pairs or singles. This strain thrives optimally at a temperature of 37.0°C, reflecting its adaptation to host-associated environments. Akkermansia muciniphila is known for its role in the gut microbiota, where it contributes to the degradation of mucin, a key component of the intestinal mucus layer. As an anaerobe, A. muciniphila str. CBA5201 is well-suited to the low-oxygen conditions prevalent in the gastrointestinal tract, allowing it to thrive in this niche while potentially influencing host health through its metabolic activities. Notably, its presence in the gut microbiome may play a crucial role in maintaining the integrity of the mucosal barrier, suggesting its involvement in the host's immune response and overall metabolic homeostasis. The unique ability of Akkermansia muciniphila to utilize mucin as a carbon source underscores its potential significance in the modulation of gut health and its impact on host-microbe interactions. Further exploration of its functional capacity may provide insights into its contributions to gut ecology and its implications for host well-being.

Taxonomy

KingdomPseudomonadati
PhylumVerrucomicrobiota
ClassVerrucomicrobiia
OrderVerrucomicrobiales
FamilyAkkermansiaceae
GenusAkkermansia
SpeciesAkkermansia muciniphila
StrainCBA5201

Profile

Physiology
Gram staining propertiesNegative
ShapeCocci
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Akkermansia muciniphila str. CBA5201
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Metazoa
Cell arrangementPairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Akkermansia muciniphila strain CBA5201 chromosome, complete

Gene Summary

Adenine Count

641282 bp

Thymine Count

636655 bp

Guanine Count

789726 bp

Cytosine Count

792744 bp

Genome Length

2860407 bp

Protein-coding Genes

2366 genes

Non-Coding Genes

66 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
lamg-like jellyroll fold domain-containing proteinAKKM5201_RS04890Not AvailablePositive1136974 - 113770225901.2
hypothetical proteinAKKM5201_RS04895Not AvailableNegative1137794 - 113860328779.3
bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase ribdAKKM5201_RS04900Not AvailablePositive1139012 - 114008239028.9
trna uridine-5-carboxymethylaminomethyl(34) synthesis enzyme mnmgAKKM5201_RS04905Not AvailableNegative1140567 - 114245368891.1
dna polymerase iii subunit deltaAKKM5201_RS04910Not AvailableNegative1142453 - 114355940763.1
trypsin-like peptidase domain-containing proteinAKKM5201_RS04915Not AvailablePositive1143811 - 114527453326.6
acetolactate synthase small subunitAKKM5201_RS04920Not AvailablePositive1145396 - 114587818222.0
atp-dependent rna helicase hrpaAKKM5201_RS04925Not AvailablePositive1145947 - 1149642140563.0
potassium channel family proteinAKKM5201_RS04930Not AvailableNegative1149735 - 115043926293.8
trkh family potassium uptake proteinAKKM5201_RS04935Not AvailableNegative1150450 - 115219863406.9

Displaying genes 991 – 1000 of 2432 in total

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Food allergyCausesPMC11210198
Thinning of the jejunum mucus layerCausesPMC7527075

Displaying health effects 1 – 2 of 2 in total