Bifidobacterium longum

Gram-positiveRodNon-motileAnaerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Bifidobacteriales

Family

Bifidobacteriaceae

Genus

Bifidobacterium

Description

Bifidobacterium longum is a Gram-positive, rod-shaped bacterium that thrives in a temperature range of 37°C to 45°C, falling under the category of mesophilic microorganisms. This bacterium is a heterotroph, meaning it obtains its energy by breaking down organic compounds, and its metabolism is characterized by aerobic respiration, where it utilizes oxygen to produce energy in the form of ATP. The bacterium is a facultative anaerobe, capable of surviving in both aerobic and anaerobic environments, although it prefers oxygen. In terms of its Gram stain, Bifidobacterium longum is classified as Gram-positive, indicating that it has a thick peptidoglycan layer in its cell wall. Its rod-shaped morphology allows it to move efficiently through its environment and colonize various body sites. As a member of the Bifidobacterium genus, B. longum is commonly found in the gastrointestinal tract of mammals, particularly in the large intestine, where it plays a crucial role in maintaining gut health. In addition to its role in the gut, B. longum can also be found in other body sites, such as the oral cavity, skin, and respiratory tract, although it is less prevalent in these locations. The bacterium's oxygen preference as a facultative anaerobe allows it to adapt to various environments, from aerobic to anaerobic conditions. Notably, Bifidobacterium longum has been implicated in various human health-related benefits, including the prevention and treatment of gastrointestinal disorders, modulation of the immune system, and production of short-chain fatty acids. Furthermore, research has shown that this bacterium can contribute to the breakdown of complex dietary fibers, making it an important player in human nutrition. Its ability to produce antimicrobial compounds also makes it a potential bioprobe for the detection of pathogens.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderBifidobacteriales
FamilyBifidobacteriaceae
GenusBifidobacterium
SpeciesBifidobacterium longum
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Bifidobacterium longum
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Metazoa, Sus scrofa
Cell arrangementClusters - Pairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNon-pathogenic

Gene Summary

Adenine Count

476478 bp

Thymine Count

481689 bp

Guanine Count

724702 bp

Cytosine Count

718567 bp

Genome Length

2401436 bp

Protein-coding Genes

2030 genes

Non-Coding Genes

81 genes

# of Chromosomes/Plasmids

10

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
two-component response regulator phopAPC1476_0368Not AvailablePositive425476 - 42624628871.0
phosphate abc transporter substrate-binding proteinAPC1476_0369Not AvailablePositive426487 - 42762039347.6
phosphate transport system permease protein pstcAPC1476_0370Not AvailablePositive427831 - 42878433679.0
phosphate abc transporter permeaseAPC1476_0371Not AvailablePositive428784 - 42978235501.4
phosphate transport atp-binding protein pstbAPC1476_0372Not AvailablePositive429835 - 43061428838.3
lema proteinAPC1476_0373Not AvailablePositive430911 - 43148921109.2
hypothetical proteinAPC1476_0374Not AvailablePositive431553 - 43381181525.5
oxidoreductase aldo/keto reductase familyAPC1476_0375Not AvailablePositive433877 - 43474031732.5
inosine-uridine preferring nucleoside hydrolaseAPC1476_0376Not AvailablePositive434838 - 43589037217.1
hypothetical proteinAPC1476_0377Not AvailableNegative435786 - 4359927662.27

Displaying genes 2551 – 2560 of 19142 in total

Metabolites

17 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000277keto-L-sorboseC6H12O6Chemical structure of keto-L-sorboseNot available
Average180.1559Da
Monoisotopic180.0633881Da
BASm0000686vanillateC8H7O4Chemical structure of vanillateNot available
Average167.1388Da
Monoisotopic167.0344337Da
BASm0001717fumarateC4H2O4Chemical structure of fumarateNot available
Average114.0563Da
Monoisotopic113.9953086Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0002751(S)-4-amino-5-oxopentanoateC5H9NO3Chemical structure of (S)-4-amino-5-oxopentanoateNot available
Average131.1299Da
Monoisotopic131.0582432Da
BASm0003112biliverdin IXalphaC33H32N4O6Chemical structure of biliverdin IXalphaNot available
Average580.642Da
Monoisotopic580.233281926Da
BASm0003389NADP(+)C21H25N7O17P3Chemical structure of NADP(+)Not available
Average740.386Da
Monoisotopic740.053624107Da
BASm0003462(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateC13H19N4O12PChemical structure of (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate3031-95-6
Average454.2833Da
Monoisotopic454.0737086Da
BASm0003971heme bC34H30FeN4O4Not available14875-96-8
Average614.484Da
Monoisotopic614.162739Da
BASm0003997Fe(II)-heme oC49H56FeN4O5Chemical structure of Fe(II)-heme oNot available
Average836.856Da
Monoisotopic836.361104Da

Displaying 1–10 of 17 metabolites

Health Effects

Health ConditionRelationReference
BacteraemiaCausesPMC12824592

Displaying health effects 1 – 1 of 1 in total