Escherichia coli CFT073

Gram-negativeRodMotileFacultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Enterobacterales

Family

Enterobacteriaceae

Genus

Escherichia

Description

Escherichia coli CFT073 is a mesophilic microbe, preferring temperatures between 20°C and 40°C, and is classified as a heterotroph, meaning it utilizes organic compounds as its energy source. This microbe is incapable of producing its own food through photosynthesis, relying instead on the breakdown of existing organic matter. Its energy production is primarily attributed to the breakdown of glucose, which is converted into ATP through cellular respiration. Gram-staining of E. coli CFT073 reveals a characteristic Gram-negative cell, consisting of an outer membrane and a thin peptidoglycan layer. The bacterium's shape is rod-shaped, also known as bacillary, with rounded ends. As a ubiquitous microbe, E. coli CFT073 can be found inhabiting various body sites, including the gastrointestinal tract of animals and humans, as well as soil, water, and plant surfaces. In terms of oxygen preference, E. coli CFT073 is a facultative anaerobe, meaning it can grow in both the presence and absence of oxygen. Additionally, it exhibits aerotolerance, allowing it to survive in environments with varying oxygen levels. This adaptability allows the microbe to thrive in a range of ecological niches, from the aerobic environments of the human gut to the anaerobic environments of soil and water. Lastly, it's worth noting that E. coli CFT073 is commonly used as a model organism in scientific research, particularly in the study of urinary tract infections. Its ability to form biofilms on bladder and kidney surfaces makes it a significant pathogen in human health, and its genetic tractability has facilitated the discovery of novel therapeutic targets.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderEnterobacterales
FamilyEnterobacteriaceae
GenusEscherichia
SpeciesEscherichia coli
StrainCFT073

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityYes
Flagellar presenceYes
Number of membranes2
Image of Escherichia coli CFT073
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Not Available
Cell arrangementPairs - Singles
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Escherichia coli CFT073, complete sequence.

Gene Summary

Adenine Count

1297551 bp

Thymine Count

1293044 bp

Guanine Count

1319228 bp

Cytosine Count

1321325 bp

Genome Length

5231428 bp

Protein-coding Genes

4748 genes

Non-Coding Genes

349 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
cu(+)/ag(+) efflux rnd transporter outer membrane channel cuscC_RS03045Q8CWA4Positive639221 - 64060350711.9
cu(+)/ag(+) efflux rnd transporter periplasmic metallochaperone cusfC_RS03050Q8CWA3Positive640627 - 64095912237.8
cu(+)/ag(+) efflux rnd transporter periplasmic adaptor subunit cusbC_RS03055Q8CWA2Positive640975 - 64219844412.4
cu(+)/ag(+) efflux rnd transporter permease subunit cusaC_RS03060Q8FK36Positive642210 - 645353114619.0
phenylalanine transporterC_RS03065P24207Positive645455 - 64683750860.6
mechanosensitive ion channel ybdgC_RS03070P0AAT4Negative646994 - 64824146639.5
oxygen-insensitive nad(p)h nitroreductaseC_RS03075P38489Negative648349 - 64900223994.4
mmcq/yjbr family dna-binding proteinC_RS03080P0AAT3Negative649081 - 64946414652.7
duf1158 domain-containing proteinC_RS03085P77506Negative649529 - 6497779403.99
ybdk family carboxylate-amine ligaseC_RS03090Q8FK30Negative649843 - 65096141649.7

Displaying genes 881 – 890 of 5097 in total

Metabolites

4934 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm0000238(R)-3-phenyllactateC9H9O3Chemical structure of (R)-3-phenyllactateNot available
Average165.169Da
Monoisotopic165.05571773Da
BASm00002482,3-dihydroxy-3-methylbutanoateC5H10O4Chemical structure of 2,3-dihydroxy-3-methylbutanoate1756-18-9
Average134.1305Da
Monoisotopic134.0579088Da
BASm00002502,5-didehydro-D-gluconateC6H7O7Chemical structure of 2,5-didehydro-D-gluconate53736-12-2
Average191.1156Da
Monoisotopic191.019177578Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm00002532-oxopent-4-enoateC5H5O3Chemical structure of 2-oxopent-4-enoateNot available
Average113.093Da
Monoisotopic113.024417601Da
BASm00002593alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da
BASm00002603alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateC24H37O5Chemical structure of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanateNot available
Average405.556Da
Monoisotopic405.264647871Da

Displaying 1–10 of 4934 metabolites

Health Effects

Health ConditionRelationReference
Urinary tract infectionCausesPMC4922710

Displaying health effects 1 – 1 of 1 in total