Streptococcus cristatus

Gram-positiveCocciFacultative anaerobe

Kingdom

Bacillati

Phylum

Bacillota

Class

Bacilli

Order

Lactobacillales

Family

Streptococcaceae

Genus

Streptococcus

Description

Streptococcus cristatus is a Gram-positive, spherical-shaped microbe that thrives in the mesophilic temperature range of 25-40°C, indicating a preference for moderate temperatures. As a chemoheterotroph, this microbe obtains its energy by breaking down organic compounds, relying on external sources of carbon and energy. Its metabolism is characterized by the production of ATP through cellular respiration, primarily relying on the citric acid cycle and oxidative phosphorylation. Streptococcus cristatus is distributed throughout various body sites, including the skin, respiratory, gastrointestinal, and genitourinary tracts, as well as the oral cavity, making it a ubiquitous inhabitant of the human host. As an obligate aerobe, this microbe requires the presence of oxygen to survive and grow, which is consistent with its ability to tolerate high levels of oxygen and thrive in aerobic environments. Physically, Streptococcus cristatus presents as small, non-motile, spherical cells that typically range in diameter from 0.5-1.5 μm. Under the Gram stain, its cell walls exhibit a characteristic blue color due to the presence of peptidoglycan, which is a key component of bacterial cell walls. Notably, Streptococcus cristatus has been linked to various diseases, such as upper respiratory tract infections, skin infections, and endocarditis. Additionally, it has been used as a model organism for studying bacterial communication and biofilm formation, providing valuable insights into the complex interactions between microorganisms and their hosts.

Taxonomy

KingdomBacillati
PhylumBacillota
ClassBacilli
OrderLactobacillales
FamilyStreptococcaceae
GenusStreptococcus
SpeciesStreptococcus cristatus
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeCocci
MobilityNot Available
Flagellar presenceYes
Number of membranesNot Available
Image of Streptococcus cristatus
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperatureNot Available
Temperature rangeNot Available
Habitatbronchoalveolar lavage fluid; mucosal surfaces of the oral cavity; oral cavity; oral mucosa; oral mucosa microbiota; tumor tissue
Biotic relationshipNot Available
Host(s)Homo sapiens
Cell arrangementChains
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Streptococcus cristatus strain CC5A TW70_contig000007, whole

Gene Summary

Adenine Count

581471 bp

Thymine Count

580211 bp

Guanine Count

454501 bp

Cytosine Count

410360 bp

Genome Length

2026543 bp

Protein-coding Genes

1924 genes

Non-Coding Genes

80 genes

# of Chromosomes/Plasmids

3

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
d-alanyl-alanine synthetase aTW70_00005A3CLS3Positive4781 - 582738862.5
5s ribosomal rnaNot AvailableNot AvailablePositive5121 - 5230Not Available
udp-n-acetylmuramoylalanine-d-glutamyl-lysine-d- alanyl-d-alanine ligaseTW70_00006P96613Positive5932 - 730550423.4
mutt/nudix family proteinTW70_00007C0SPC3Positive7292 - 790323264.6
integral membrane proteinTW70_00008Not AvailablePositive8095 - 878726433.1
integral membrane proteinTW70_00009Not AvailablePositive8896 - 957625837.2
peptide chain release factor 3TW70_00010Q97SE4Positive9872 - 1141658506.7
magnesium and cobalt transporter coraTW70_00011Not AvailablePositive11734 - 1264535202.3
abc transporter atp-binding proteinTW70_00012C0SPB4Positive12826 - 1371933434.6
abc-2 family transporter proteinTW70_00013O07523Positive13716 - 1493044344.7

Displaying genes 11 – 20 of 3987 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

268 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm00006473-hydroxypropanoateC3H5O3Chemical structure of 3-hydroxypropanoateNot available
Average89.071Da
Monoisotopic89.0244176Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001086scyllo-inososeC6H10O6Chemical structure of scyllo-inososeNot available
Average178.14Da
Monoisotopic178.0477381Da
BASm0001140cyclohexyl isocyanideC7H11NChemical structure of cyclohexyl isocyanideNot available
Average109.1689Da
Monoisotopic109.089149357Da
BASm0001142butanoateC4H7O2Chemical structure of butanoateNot available
Average87.099Da
Monoisotopic87.045153045Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001279(6S)-5-methyl-5,6,7,8-tetrahydrofolateC20H23N7O6Chemical structure of (6S)-5-methyl-5,6,7,8-tetrahydrofolateNot available
Average457.4399Da
Monoisotopic457.1709815Da

Displaying 1–10 of 268 metabolites

Health Effects

Health ConditionRelationReference
BacteremiaCausesPMC10188223
Infective endocarditisCausesPMC10188223
IeCausesPMC10188223
PneumoniaCausesPMC11157216
Community-acquired pneumoniaCausesPMC11157216
CapCausesPMC11157216
Community-acquired pneumonia (cap)CausesPMC11157216
BacteremiaCausesPMC11157216

Displaying health effects 1 – 8 of 8 in total