Staphylococcus capitis

Gram-positiveCocciFacultative anaerobe

Kingdom

Bacillati

Phylum

Bacillota

Class

Bacilli

Order

Caryophanales

Family

Staphylococcaceae

Genus

Staphylococcus

Description

Staphylococcus capitis, a ubiquitous microbe, is a Gram-positive, spherical-shaped bacterium that thrives in temperatures ranging from 20°C to 40°C, falling under the category of mesophiles. As a chemoheterotroph, it relies on complex organic compounds as its energy source, breaking them down anaerobically to produce ATP through fermentation. S. capitis is found in almost all body sites across all human species, including the skin, mucous membranes, and respiratory, gastrointestinal, and genitourinary tracts. Its ability to inhabit diverse environments is attributed to its remarkable adaptability and robustness. As an obligate anaerobe, S. capitis requires an oxygen-free environment to survive and multiply. It is unable to tolerate even low levels of oxygen, making it highly susceptible to oxidative stress. However, this anaerobic nature also allows it to thrive in environments where other microorganisms may struggle to survive. In terms of energy production, S. capitis employs a unique mechanism, relying on the breakdown of amino acids, sugars, and other organic compounds to generate ATP. This process involves the conversion of glucose into lactic acid, a key byproduct of anaerobic metabolism. Interestingly, S. capitis has been linked to various human diseases, including skin infections, sepsis, and endocarditis. Moreover, it has been found to play a role in the development of biofilms, complex communities of microorganisms that adhere to surfaces and are notoriously difficult to eradicate. S. capitis is also known to exhibit an impressive ability to develop resistance to antimicrobial agents, making it a significant public health concern. Its capacity to survive and thrive in the face of antimicrobial stress is largely attributed to its ability to adapt and evolve rapidly, rendering traditional treatment approaches less effective.

Taxonomy

KingdomBacillati
PhylumBacillota
ClassBacilli
OrderCaryophanales
FamilyStaphylococcaceae
GenusStaphylococcus
SpeciesStaphylococcus capitis
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeCocci
MobilityNot Available
Flagellar presenceYes
Number of membranesNot Available
Image of Staphylococcus capitis
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsFacultative anaerobe
Optimal temperatureNot Available
Temperature rangeNot Available
Habitatneonatal intensive care units (NICUs); pork meat; skin; skin surface of the foot
Biotic relationshipNot Available
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Staphylococcus capitis genome assembly CR03, contig

Gene Summary

Adenine Count

827874 bp

Thymine Count

855418 bp

Guanine Count

394123 bp

Cytosine Count

427937 bp

Genome Length

2505352 bp

Protein-coding Genes

2384 genes

Non-Coding Genes

139 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
AttlNot AvailableNot AvailablePositive824645 - 824658Not Available
Dna-binding proteinBN1517130009Not AvailableNegative828901 - 8290987578.04
Hypothetical proteinBN1517130010Not AvailableNegative830048 - 8302337153.68
Glycyl-glycine endopeptidase ale-1 precursorBN1517130011Not AvailableNegative830714 - 83217755342.5
HolinBN1517130012Not AvailableNegative832152 - 83256214512.9
Hypothetical proteinBN1517130013Not AvailableNegative832607 - 83314020486.3
Hypothetical proteinBN1517130014Not AvailableNegative833140 - 83365519481.7
Hypothetical proteinBN1517130015Not AvailableNegative833697 - 8338435770.91
Hypothetical proteinBN1517130016Not AvailableNegative833836 - 83418013122.3
Tail proteinBN1517130017Not AvailableNegative834192 - 83585061262.7

Displaying genes 1 – 10 of 2523 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

346 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000893crotonobetaineC7H13NO2Chemical structure of crotonobetaine927-89-9
Average143.1836Da
Monoisotopic143.0946287Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001639CobinamideC48H72CoN11O8Chemical structure of Cobinamide13497-85-3
Average990.0874Da
Monoisotopic989.4897335Da
BASm0001661Cu(2+)CuChemical structure of Cu(2+)7440-50-8
Average63.546Da
Monoisotopic62.929601079Da
BASm0001921(S)-3-methyl-2-oxopentanoateC6H9O3Chemical structure of (S)-3-methyl-2-oxopentanoate1460-34-0
Average129.1339Da
Monoisotopic129.0551692Da
BASm0002026acrylateC3H3O2Chemical structure of acrylate10344-93-1
Average71.056Da
Monoisotopic71.013852917Da

Displaying 1–10 of 346 metabolites

Health Effects

Health ConditionRelationReference
Healthcare-acquired infectionsCausesPMC6437968
HaisCausesPMC6437968
SepticaemiaCausesPMC8393854
Septic meningitisCausesPMC8393854
Skin infectionsCausesPMC9392311
Bloodstream infectionsCausesPMC9392311
SepsisCausesPMC9392311

Displaying health effects 1 – 7 of 7 in total