Mycobacterium avium

Gram-positiveRodNon-motileMicroaerophile

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Mycobacteriales

Family

Mycobacteriaceae

Genus

Mycobacterium

Description

Mycobacterium avium is a mesophilic microbe, preferring temperatures between 25-40°C, and is a heterotroph, deriving its energy from organic molecules. It employs aerobic respiration as its primary method of energy production, utilizing oxygen to break down its carbon-based energy sources. As a Gram-positive bacterium, M. avium's cell wall is composed of a thick peptidoglycan layer, which gives it a distinctive staining characteristic. Its shape is typically coccobacillary, with smooth, non-motile, and non-spore-forming cells. M. avium can be found in various body sites, including the respiratory tract, skin, and gastrointestinal tract, across all mammalian species. Its presence is often asymptomatic, but it can also cause opportunistic infections in individuals with compromised immune systems. The microbe is an obligate aerobe, requiring a constant supply of oxygen to survive. It thrives in environments with moderate to high levels of oxygen, such as the human lung and intestinal tract. One notable characteristic of M. avium is its ability to form biofilms, complex communities of microorganisms attached to surfaces. This allows it to adapt to its environment and resist host immune responses. In addition to its biological characteristics, M. avium has gained significant attention in recent years due to its potential role in the development of disease. The microbe's ability to form biofilms and evade host immune responses makes it a challenging target for treatment, and its presence has been implicated in various respiratory and gastrointestinal disorders. Furthermore, the increasing prevalence of antibiotic-resistant strains has led to increased research into the development of novel therapeutic strategies against M. avium.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderMycobacteriales
FamilyMycobacteriaceae
GenusMycobacterium
SpeciesMycobacterium avium
StrainNo strain

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes1
Image of Mycobacterium avium
AI-generated image based on bacteria physiology
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophile
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Bos taurus, Bos
Cell arrangementSingles
SporulationNot Available
Energy sourceChemoorganotroph
PathogenicityNot Available

Genome Summary

Mycobacterium avium strain FLAC0371

Gene Summary

Adenine Count

827038 bp

Thymine Count

828601 bp

Guanine Count

1836406 bp

Cytosine Count

1843130 bp

Genome Length

5335175 bp

Protein-coding Genes

4816 genes

Non-Coding Genes

53 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
mmpl family rnd transporterCKJ75_17505Not AvailableNegative3695138 - 3698056105091.0
transport acessory protein mmpsCKJ75_17510Not AvailableNegative3698053 - 369845714223.0
pyridoxamine 5'-phosphate oxidaseCKJ75_17515Not AvailablePositive3698703 - 369922118154.3
tetr family transcriptional regulatorCKJ75_17520Not AvailableNegative3699232 - 369983421955.3
cystathionine gamma-lyaseCKJ75_17525Not AvailableNegative3699908 - 370102038366.6
nad-dependent dna ligase ligaCKJ75_17530Not AvailableNegative3701025 - 370310675361.6
methionine synthaseCKJ75_17535Not AvailableNegative3703161 - 370418934823.7
sensor domain-containing proteinCKJ75_17540Not AvailablePositive3704288 - 370493222303.5
trna(5-methylaminomethyl-2-thiouridine)- methyltransferaseCKJ75_17545Not AvailableNegative3704940 - 370601637544.5
cysteine desulfuraseCKJ75_17550Not AvailableNegative3706017 - 370719540575.3

Displaying genes 3351 – 3360 of 4869 in total

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

38 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000848hexanoateC6H11O2Chemical structure of hexanoateNot available
Average115.1503Da
Monoisotopic115.075904596Da
BASm0001210alpha,alpha'-trehalose 6,6'-bismycolateC76H142O15Chemical structure of alpha,alpha'-trehalose 6,6'-bismycolateNot available
Average1295.957Da
Monoisotopic1295.034874Da
BASm0001216alpha,alpha'-trehalose 6-mycolateC44H82O13Chemical structure of alpha,alpha'-trehalose 6-mycolateNot available
Average819.127Da
Monoisotopic818.5755427Da
BASm0001225dodecanoateC12H23O2Chemical structure of dodecanoateNot available
Average199.3098Da
Monoisotopic199.169805Da
BASm0001429decanoateC10H19O2Chemical structure of decanoateNot available
Average171.2567Da
Monoisotopic171.138504852Da
BASm0001774tetradecanoateC14H27O2Chemical structure of tetradecanoateNot available
Average227.363Da
Monoisotopic227.2011051Da
BASm0001775(9Z)-octadecenoateC18H33O2Chemical structure of (9Z)-octadecenoateNot available
Average281.4534Da
Monoisotopic281.2480553Da
BASm0001842(5Z,8Z,11Z,14Z)-eicosatetraenoateC20H31O2Chemical structure of (5Z,8Z,11Z,14Z)-eicosatetraenoateNot available
Average303.467Da
Monoisotopic303.2329538Da
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0002305(S)-2-ethyl-2-hydroxy-3-oxobutanoateC6H9O4Chemical structure of (S)-2-ethyl-2-hydroxy-3-oxobutanoateNot available
Average145.135Da
Monoisotopic145.0506324Da

Displaying 1–10 of 38 metabolites

Health Effects

Health ConditionRelationReference
NecrosisCausesPMC11064574
Lung infectionsCausesPMC11807137
TuberculosisCausesPMC12017052
Chronic pulmonary and disseminated infectionsCausesPMC12871676
Hypersensitivity-like lung diseaseCausesPMC4589115
Hot tub lungCausesPMC4589115
SpnCausesPMC8272905
PleuritisCausesPMC8272905
Pulmonary diseaseCausesPMC12822083
Pulmonary infectionCausesPMC12822083

Displaying health effects 1 – 10 of 17 in total