Bifidobacterium breve str. CNCM I-4321

Gram-positiveRodAnaerobe

Kingdom

Bacillati

Phylum

Actinomycetota

Class

Actinomycetes

Order

Bifidobacteriales

Family

Bifidobacteriaceae

Genus

Bifidobacterium

Description

Bifidobacterium breve str. CNCM I-4321 is a Gram-positive, anaerobic bacterium predominantly found in the gastrointestinal tract, particularly within the gut microbiota of healthy newborns and infants, as well as in human breast milk. This strain is part of a diverse community of beneficial microbes that inhabit the intestines, playing a crucial role in gut health and development during early life. This species thrives in anaerobic conditions, which are characteristic of the gut environment, facilitating its growth and activity in the absence of oxygen. Its presence in human breast milk underscores its importance in shaping the infant gut microbiome, as it may contribute to the establishment of a healthy microbial community essential for proper digestion and immune system development. Bifidobacterium breve str. CNCM I-4321's adaptation to the infant intestine suggests a specialized role in metabolizing human milk oligosaccharides, which are abundant in breast milk. This unique ability not only aids in the digestion of these complex carbohydrates but may also enhance the overall health of the infant by promoting a balanced gut microbiota. Consequently, understanding the functional capabilities of this strain could provide insights into its potential applications in probiotic formulations targeted at improving infant health and development.

Taxonomy

KingdomBacillati
PhylumActinomycetota
ClassActinomycetes
OrderBifidobacteriales
FamilyBifidobacteriaceae
GenusBifidobacterium
SpeciesBifidobacterium breve
StrainCNCM I-4321

Profile

Physiology
Gram staining propertiesPositive
ShapeRod
MobilityNot Available
Flagellar presenceYes
Number of membranesNot Available
Image of Bifidobacterium breve str. CNCM I-4321
AI-generated image based on bacteria physiology
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperatureNot Available
Temperature rangeNot Available
Habitatbreast milk; gastrointestinal tract; gut; human breast milk; human gut; infant gut microbiota; infant intestine; intestines; microbiota of healthy newborns
Biotic relationshipNot Available
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNonsporulating
Energy sourceNot Available
PathogenicityNot Available

Genome Summary

Bifidobacterium breve strain CNCM I-4321 chromosome, complete

Gene Summary

Adenine Count

507424 bp

Thymine Count

504369 bp

Guanine Count

723847 bp

Cytosine Count

729212 bp

Genome Length

2464852 bp

Protein-coding Genes

2082 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
adp-forming succinate--coa ligase subunit betaCNCMI4321_RS05620Not AvailablePositive1222131 - 122333342755.3
succinate--coa ligase subunit alphaCNCMI4321_RS05625Not AvailablePositive1223333 - 122424430920.6
duf6350 family proteinCNCMI4321_RS05630Not AvailablePositive1224264 - 122564949648.4
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/imp cyclohydrolaseCNCMI4321_RS05635Not AvailablePositive1225597 - 122723458371.9
hypothetical proteinCNCMI4321_RS11875Not AvailablePositive1227389 - 122769110916.5
mip/aquaporin family proteinCNCMI4321_RS05645Not AvailableNegative1227590 - 122852832326.7
pseudouridine synthaseCNCMI4321_RS05650Not AvailablePositive1228717 - 122948728847.0
bifunctional cytidylate kinase/gtpase derCNCMI4321_RS05655Not AvailablePositive1229484 - 123161077643.7
Trna-proNot AvailableNot AvailablePositive1231737 - 1231810Not Available
cof-type had-iib family hydrolaseCNCMI4321_RS05665Not AvailablePositive1231873 - 123271231394.0

Displaying genes 1161 – 1170 of 2222 in total

Metabolites

2 records
Metabolite IDMetabolite nameStructureCAS number
BASm0001865diphosphateHO7P2Chemical structure of diphosphateNot available
Average174.95Da
Monoisotopic174.9213971Da
BASm0014029(S)-3-Hydroxyisobutyric acidC19H35N5O6SeChemical structure of (S)-3-Hydroxyisobutyric acid26543-05-5
Average508.489Da
Monoisotopic509.175256Da

Displaying 1–2 of 2 metabolites

Health Effects

No health effects information available for this bacterium.