Fusobacterium nucleatum

Gram-negativeRodNon-motileAnaerobe

Kingdom

Fusobacteriati

Phylum

Fusobacteriota

Class

Fusobacteriia

Order

Fusobacteriales

Family

Fusobacteriaceae

Genus

Fusobacterium

Description

Fusobacterium nucleatum is a Gram-negative, non-sporulating rod-shaped bacterium commonly found in anaerobic environments, typically associated with host organisms. It primarily exists in pairs and is characterized by its lack of motility, despite possessing true flagella. This microbe is a chemoheterotroph, deriving energy from organic compounds, and thrives optimally at a temperature of 37°C, classifying it as mesophilic. Fusobacterium nucleatum is notable for its free-living biotic relationship within host-associated habitats, indicating a potential role in the microbiota of various animal species. The organism has two cellular membranes, a trait common among Gram-negative bacteria, and contains two replicons within its genome, which is cataloged under the accessions MLQO00000000.1 and PNHC00000000.1. Understanding the ecological role of Fusobacterium nucleatum is crucial, particularly in the context of its presence in the host microbiome, where it may influence health and disease states. The bacterium's association with animal hosts suggests an intricate relationship that may impact the overall microbial community and host interactions.

Taxonomy

KingdomFusobacteriati
PhylumFusobacteriota
ClassFusobacteriia
OrderFusobacteriales
FamilyFusobacteriaceae
GenusFusobacterium
SpeciesFusobacterium nucleatum
StrainNo strain

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Fusobacterium nucleatum
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAnaerobe
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Oryctolagus cuniculus
Cell arrangementPairs
SporulationNonsporulating
Energy sourceChemoheterotroph
PathogenicityAnimal

Genome Summary

Fusobacterium nucleatum strain UMB0249 .16933_8_42.27, whole

Gene Summary

Adenine Count

906952 bp

Thymine Count

890038 bp

Guanine Count

335938 bp

Cytosine Count

322474 bp

Genome Length

2455598 bp

Protein-coding Genes

2224 genes

Non-Coding Genes

55 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
aminobenzoyl-glutamate transporterBKN39_09170Not AvailablePositive1972058 - 197359654870.7
cell surface proteinBKN39_09175Not AvailablePositive1973824 - 197557860599.7
death-on-curing proteinBKN39_09180Not AvailablePositive1976078 - 197646114389.6
rrf2 family transcriptional regulatorBKN39_09190Not AvailableNegative1977686 - 197811116236.8
hypothetical proteinBKN39_09195Not AvailableNegative1978142 - 197905033507.5
serine/threonine protein phosphataseBKN39_09200Not AvailableNegative1979065 - 198058858422.4
excinuclease abc subunit cBKN39_09205Not AvailableNegative1980653 - 198242268650.8
rnase adaptor protein rapzBKN39_09210Not AvailableNegative1982409 - 198327533313.8
coa-disulfide reductaseBKN39_09215Not AvailableNegative1983297 - 198464649706.9
4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis proteinBKN39_09220Not AvailableNegative1984791 - 198533920023.1

Displaying genes 4071 – 4080 of 4228 in total

Pathways

22 pathways

No pathways found

No metabolic pathways have been associated with this bacterium yet.

Metabolites

303 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000173(R)-3-Hydroxybutyric acidC4H8O3Chemical structure of (R)-3-Hydroxybutyric acid625-72-3
Average104.0473Da
Monoisotopic104.047344122Da
BASm0000217alpha-ribazoleC14H18N2O4Chemical structure of alpha-ribazoleNot available
Average278.3037Da
Monoisotopic278.126657074Da
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000277keto-L-sorboseC6H12O6Chemical structure of keto-L-sorboseNot available
Average180.1559Da
Monoisotopic180.0633881Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000686vanillateC8H7O4Chemical structure of vanillateNot available
Average167.1388Da
Monoisotopic167.0344337Da
BASm0000989GlycerolC3H8O3Chemical structure of Glycerol56-81-5
Average92.0938Da
Monoisotopic92.04734412Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da

Displaying 1–10 of 303 metabolites

Health Effects

Health ConditionRelationReference
Lemierre s syndromeCausesPMC9009667
Colorectal cancerCausesPMC10394142
Gingival diseasesCausesPMC9318310
Dental infectionsCausesPMC9318310
Colorectal cancerCausesPMC11767858
CarcinogenicCausesPMC11792494
Chronic oral and intestinal diseasesCausesPMC8604900
OsccCausesPMC12001643

Displaying health effects 1 – 8 of 8 in total