Neisseria gonorrhoeae

Gram-negativeCocciNon-motileAerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Betaproteobacteria

Order

Neisseriales

Family

Neisseriaceae

Genus

Neisseria

Description

Neisseria gonorrhoeae is a Gram-negative bacterium characterized by its cocci shape and arrangement in singles and pairs. This organism is non-motile and lacks flagella, which is consistent with its adaptation to a host-associated habitat. N. gonorrhoeae requires an aerobic environment for growth, thriving optimally at a temperature of 35°C, which classifies it as mesophilic. The bacterium possesses a unique cellular structure with two membranes surrounding its cell wall, a feature typical of Gram-negative organisms. N. gonorrhoeae exhibits a free-living biotic relationship, although it is primarily known for its association with human hosts, where it can cause infections. It has been observed to contain 24 genomic replicons, indicating a complex genetic architecture that may contribute to its adaptability and survival in varying environments. The presence of multiple genome accessions, including SURC00000000.1 and SUQU00000000.1, suggests a considerable genetic diversity within the species, which could play a role in its pathogenicity and resistance mechanisms. Understanding the genomic variability of N. gonorrhoeae could provide insights into its evolutionary strategies and potential challenges in treatment and control measures. This microbe's ecological niche emphasizes its close association with human hosts, reflecting its adaptation to a specific ecological context while also highlighting the potential for environmental influences on its genetic diversity.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassBetaproteobacteria
OrderNeisseriales
FamilyNeisseriaceae
GenusNeisseria
SpeciesNeisseria gonorrhoeae
StrainNo strain

Profile

Physiology
Gram staining propertiesNegative
ShapeCocci
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Neisseria gonorrhoeae
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Mammalia
Cell arrangementSingles - Pairs
SporulationNot Available
Energy sourceNot Available
PathogenicityNot Available

Gene Summary

Adenine Count

513093 bp

Thymine Count

511521 bp

Guanine Count

557910 bp

Cytosine Count

570289 bp

Genome Length

2160498 bp

Protein-coding Genes

2225 genes

Non-Coding Genes

86 genes

# of Chromosomes/Plasmids

24

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
uracil phosphoribosyltransferaseEPH42_00430Not AvailableNegative76776 - 7740222879.0
hypothetical proteinEPH42_00435Not AvailableNegative77392 - 775084411.4
grx4 family monothiol glutaredoxinEPH42_00440Not AvailableNegative77508 - 7781911494.8
duf333 domain-containing proteinEPH42_00445Not AvailableNegative77920 - 781357990.59
tatd family deoxyribonucleaseEPH42_00450Not AvailableNegative78161 - 7894028734.1
pilus assembly protein pilzEPH42_00455Not AvailableNegative78945 - 7929512797.6
dna polymerase iii subunit delta'EPH42_00460Not AvailableNegative79299 - 8027637011.3
pilt/pilu family type 4a pilus atpaseEPH42_00465Not AvailableNegative80310 - 8144042217.8
5'-methylthioadenosine/adenosylhomocysteine nucleosidaseEPH42_00470Not AvailablePositive81608 - 8230924825.9
elongation factor 4EPH42_00475Not AvailablePositive82451 - 8424466006.0

Displaying genes 161 – 170 of 56816 in total

Metabolites

126 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000401(S)-2-succinylamino-6-oxoheptanedioateC11H12NO8Chemical structure of (S)-2-succinylamino-6-oxoheptanedioateNot available
Average286.218Da
Monoisotopic286.0579371Da
BASm0000433malonateC3H2O4Chemical structure of malonateNot available
Average102.0456Da
Monoisotopic101.9953086Da
BASm00005275-oxopentanoateC5H7O3Chemical structure of 5-oxopentanoateNot available
Average115.109Da
Monoisotopic115.040067665Da
BASm0000642S-adenosyl-4-methylsulfanyl-2-oxobutanoateC15H19N5O6SChemical structure of S-adenosyl-4-methylsulfanyl-2-oxobutanoateNot available
Average397.406Da
Monoisotopic397.105604055Da
BASm0000848hexanoateC6H11O2Chemical structure of hexanoateNot available
Average115.1503Da
Monoisotopic115.075904596Da
BASm00008763-hydroxypyruvateC3H3O4Chemical structure of 3-hydroxypyruvateNot available
Average103.054Da
Monoisotopic103.003682157Da

Displaying 1–10 of 126 metabolites

Health Effects

Health ConditionRelationReference
GonorrheaCausesPMC11658436
Eye infectionsCausesPMC11658436
ConjunctivitisCausesPMC11658436
SepticemiaCausesPMC11658436
Male urethritisCausesPMC13191610
GonorrheaCausesPMC1538595
Disseminated gonococcal infectionsCausesPMC1538595
GonorrhoeaCausesPMC3943661
GonorrheaCausesPMC9657967
Disseminated infectionsCausesPMC9657967

Displaying health effects 1 – 10 of 14 in total