Helicobacter pylori str. ZH88

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain ZH88 is a Gram-negative, microaerophilic bacterium characterized by its spirilla shape and single-cell arrangement. This organism thrives optimally at a temperature of 37.0 degrees Celsius, which aligns with its habitat as a host-associated microbe, typically found in the gastric mucosa of the stomach. As a member of the Helicobacter genus, H. pylori is known for its distinctive spiral morphology, which may facilitate its motility through viscous environments, such as gastric mucus. The microaerophilic nature of this strain indicates that it requires reduced levels of oxygen for growth, a condition prevalent in the gastric environment, where oxygen concentration is lower than in the atmosphere. Understanding the specific growth requirements and morphological traits of H. pylori strain ZH88 is crucial for elucidating its interactions with host systems and potential implications for human health. Given its adaptation to life in the stomach, this strain may provide insights into the mechanisms by which gastric-associated bacteria navigate extreme environments and maintain their viability in the presence of gastric acid and other defensive host factors.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
StrainZH88

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori str. ZH88
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain ZH88 35, whole genome shotgun sequence.

Gene Summary

Adenine Count

505660 bp

Thymine Count

502613 bp

Guanine Count

319675 bp

Cytosine Count

320845 bp

Genome Length

1651403 bp

Protein-coding Genes

1474 genes

Non-Coding Genes

42 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
glutamate--trna ligaseEC538_00005Not AvailablePositive106 - 149753343.2
5s ribosomal rnaNot AvailableNot AvailablePositive146 - 263Not Available
16s ribosomal rnaNot AvailableNot AvailablePositive298 - 1806Not Available
23s ribosomal rnaNot AvailableNot AvailablePositive498 - 3384Not Available
sulfate/molybdate abc transporter atp-binding proteinEC538_00010Not AvailableNegative1613 - 241030189.9
molybdate abc transporter permease subunitEC538_00015Not AvailableNegative2407 - 308124791.2
molybdate abc transporter substrate-binding proteinEC538_00020Not AvailableNegative3104 - 384427511.8
orotate phosphoribosyltransferaseEC538_00025Not AvailablePositive3863 - 39584011.98
outer membrane beta-barrel proteinEC538_00030Not AvailablePositive4070 - 463020910.0
hypothetical proteinEC538_00035Not AvailablePositive4614 - 47966790.38

Displaying genes 1 – 10 of 1516 in total

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Carcinoma of the stomachCausesPMC8882093
GastritisCausesPMC8882093
GcCausesPMC8882093
Acute gastric ulcersCausesPMC9330504
Chronic gastritisCausesPMC12516687
Peptic and duodenal ulcerationCausesPMC12516687
Gastric cancerCausesPMC10587687
GcCausesPMC10587687
Gastric non-cardia carcinomasCausesPMC6805339
DyspepsiaCausesPMC11999147

Displaying health effects 51 – 60 of 94 in total