Helicobacter pylori str. ZH88

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain ZH88 is a Gram-negative, microaerophilic bacterium characterized by its spirilla shape and single-cell arrangement. This organism thrives optimally at a temperature of 37.0 degrees Celsius, which aligns with its habitat as a host-associated microbe, typically found in the gastric mucosa of the stomach. As a member of the Helicobacter genus, H. pylori is known for its distinctive spiral morphology, which may facilitate its motility through viscous environments, such as gastric mucus. The microaerophilic nature of this strain indicates that it requires reduced levels of oxygen for growth, a condition prevalent in the gastric environment, where oxygen concentration is lower than in the atmosphere. Understanding the specific growth requirements and morphological traits of H. pylori strain ZH88 is crucial for elucidating its interactions with host systems and potential implications for human health. Given its adaptation to life in the stomach, this strain may provide insights into the mechanisms by which gastric-associated bacteria navigate extreme environments and maintain their viability in the presence of gastric acid and other defensive host factors.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
StrainZH88

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori str. ZH88
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain ZH88 35, whole genome shotgun sequence.

Gene Summary

Adenine Count

505660 bp

Thymine Count

502613 bp

Guanine Count

319675 bp

Cytosine Count

320845 bp

Genome Length

1651403 bp

Protein-coding Genes

1474 genes

Non-Coding Genes

42 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
holo-acp synthaseEC538_01120Not AvailablePositive214858 - 21521713078.2
ligand-gated channelEC538_01125Not AvailablePositive215426 - 21780489547.5
m48 family peptidaseEC538_01130Not AvailableNegative217815 - 21843524106.6
glycosyltransferase family 25 proteinEC538_01135Not AvailablePositive218517 - 21937132928.5
bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/gtp cyclohydrolase iiEC538_01140Not AvailablePositive219538 - 22057238918.1
duf3943 domain-containing proteinEC538_01145Not AvailablePositive220659 - 22149832190.8
gtp cyclohydrolase iiEC538_01150Not AvailablePositive221587 - 22216521730.3
moad/this family proteinEC538_01155Not AvailablePositive222239 - 2224638267.16
molybdenum cofactor biosynthesis protein moaeEC538_01160Not AvailablePositive222464 - 22290116476.1
molybdopterin adenylyltransferaseEC538_01165Not AvailablePositive222914 - 22344419650.0

Displaying genes 221 – 230 of 1516 in total

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total