Helicobacter pylori str. ZH72

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori str. ZH72 is a Gram-negative bacterium characterized by its spiral shape and single-cell arrangement. This microbe demonstrates an optimal growth temperature of 37.0°C, indicating its adaptation to the human body, where it is primarily found as a host-associated organism. H. pylori str. ZH72 exhibits microaerophilic oxygen requirements, thriving in environments with reduced oxygen levels, which is characteristic of its niche in the gastric mucosa. The unique morphology of H. pylori, coupled with its specific growth conditions, underscores its specialized lifestyle in the gastric environment. The microaerophilic nature of this strain may suggest an evolutionary adaptation allowing it to evade the host's immune response while exploiting the nutrient-rich conditions of the stomach lining. Understanding the traits of H. pylori str. ZH72 can provide insights into its ecological role within the human gastric microbiome, as it may influence local pH levels and interact with other microbial communities present in the host's gastrointestinal tract. Further investigation into the ecological interactions and metabolic capabilities of this strain could enhance our understanding of its role in health and disease.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
StrainZH72

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori str. ZH72
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain ZH72 40, whole genome shotgun sequence.

Gene Summary

Adenine Count

492536 bp

Thymine Count

487957 bp

Guanine Count

312949 bp

Cytosine Count

312723 bp

Genome Length

1609121 bp

Protein-coding Genes

1451 genes

Non-Coding Genes

41 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
bifunctional 2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase/2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthaseEC520_01250Not AvailablePositive258578 - 25979845426.0
response regulatorEC520_01255Not AvailablePositive259820 - 26071635113.4
5'-3' exonucleaseEC520_01265Not AvailablePositive260972 - 26180832731.7
hypothetical proteinEC520_01270Not AvailableNegative261914 - 26316446842.1
j domain-containing proteinEC520_01275Not AvailablePositive263332 - 26419832888.1
merr family transcriptional regulatorEC520_01280Not AvailablePositive264208 - 26457914348.5
aaa family atpaseEC520_01285Not AvailablePositive264576 - 26575143734.6
transcriptional repressorEC520_01290Not AvailablePositive265911 - 26636317682.4
duf2147 domain-containing proteinEC520_01295Not AvailableNegative266383 - 26688019045.8
duf386 family proteinEC520_01300Not AvailableNegative266877 - 26741320254.5

Displaying genes 241 – 250 of 1492 in total

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total