Helicobacter pylori str. UM163

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain UM163 is a microaerophilic, Gram-negative bacterium characterized by its spirilla shape and single-cell arrangement. This organism thrives at an optimal temperature of 37.0°C, indicating its adaptation to the human body, which serves as its primary habitat. As a host-associated microbe, H. pylori UM163 is intimately linked to the gastric environment, where it may influence various physiological processes. The microaerophilic nature of this strain suggests that it requires reduced oxygen levels for growth, which aligns with its gastric niche, where oxygen concentrations are lower than in the external environment. This adaptation could be crucial for its survival and function within the host's stomach, allowing it to evade the immune response while colonizing the mucosal lining. Understanding the specific traits of H. pylori UM163 provides insights into its ecological role in the human gastrointestinal tract. Its ability to thrive in a microaerophilic environment highlights the unique adaptations that bacteria can develop to exploit specific niches within host organisms. Further exploration of its interactions with the host and the implications for gastric health could reveal important aspects of microbial ecology and human health.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
StrainUM163

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori str. UM163
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain UM163 Contig_9_UM163, whole genome

Gene Summary

Adenine Count

510168 bp

Thymine Count

508811 bp

Guanine Count

318516 bp

Cytosine Count

318824 bp

Genome Length

1656397 bp

Protein-coding Genes

1487 genes

Non-Coding Genes

42 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
30s ribosomal protein s9AK968_04390B5Z683Negative927205 - 92759414508.9
50s ribosomal protein l13AK968_04395B5Z684Negative927591 - 92801616142.9
hypothetical proteinAK968_04400P64652Negative928311 - 9284997230.22
malate:quinone oxidoreductaseAK968_04405Q1CV68Negative928506 - 92985850687.2
hypothetical proteinAK968_04410Not AvailableNegative929912 - 93127651977.6
rna polymerase subunit sigmaAK968_04415P55993Negative931297 - 93330977682.5
hypothetical proteinAK968_04425Not AvailablePositive934315 - 93460811605.4
virb2 type iv secretion proteinAK968_04435Not AvailablePositive936163 - 93643810352.0
virb3 type iv secretion proteinAK968_04440Not AvailablePositive936439 - 93670510163.5
hypothetical proteinAK968_04450Not AvailablePositive938551 - 93902117623.5

Displaying genes 841 – 850 of 1529 in total

Metabolites

92 records
Metabolite IDMetabolite nameStructureCAS number
BASm0000237(R)-4'-phosphopantothenateC9H18NO8PChemical structure of (R)-4'-phosphopantothenateNot available
Average299.2149Da
Monoisotopic299.0770031Da
BASm00002512-dehydropantoateC6H9O4Chemical structure of 2-dehydropantoateNot available
Average145.1333Da
Monoisotopic145.050083776Da
BASm0000377(S)-malateC4H4O5Chemical structure of (S)-malateNot available
Average132.0716Da
Monoisotopic132.005873238Da
BASm0000387(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateC20H21N7O6Chemical structure of (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateNot available
Average455.432Da
Monoisotopic455.1564286Da
BASm0000401(S)-2-succinylamino-6-oxoheptanedioateC11H12NO8Chemical structure of (S)-2-succinylamino-6-oxoheptanedioateNot available
Average286.218Da
Monoisotopic286.0579371Da
BASm0000642S-adenosyl-4-methylsulfanyl-2-oxobutanoateC15H19N5O6SChemical structure of S-adenosyl-4-methylsulfanyl-2-oxobutanoateNot available
Average397.406Da
Monoisotopic397.105604055Da
BASm0001167triphosphateO10P3Chemical structure of triphosphate14127-68-5
Average252.9153Da
Monoisotopic252.8704308Da
BASm0001697(S)-4,5-dihydroxypentane-2,3-dioneC5H8O4Chemical structure of (S)-4,5-dihydroxypentane-2,3-dioneNot available
Average132.1146Da
Monoisotopic132.042258744Da
BASm0001717fumarateC4H2O4Chemical structure of fumarateNot available
Average114.0563Da
Monoisotopic113.9953086Da
BASm0001779orotateC5H3N2O4Chemical structure of orotateNot available
Average155.09Da
Monoisotopic155.0098302Da

Displaying 1–10 of 92 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total