Helicobacter pylori str. 22368

Gram-negativeSpirillaNon-motileMicroaerophilic

Kingdom

Pseudomonadati

Phylum

Campylobacterota

Class

Epsilonproteobacteria

Order

Campylobacterales

Family

Helicobacteraceae

Genus

Helicobacter

Description

Helicobacter pylori strain 22368 is a Gram-negative, microaerophilic bacterium characterized by its spirilla shape and single-cell arrangement. This organism thrives optimally at a temperature of 37.0°C, suggesting its adaptation to the warm environment of the human gastric niche. As a host-associated microbe, Helicobacter pylori strain 22368 is commonly found in the stomach lining of its hosts, where it plays a role in complex interactions with the gastric environment. The microaerophilic nature of Helicobacter pylori indicates that it requires reduced levels of oxygen for growth, which aligns with its habitat within the human stomach, where oxygen concentration is lower than in the atmosphere. The unique morphological characteristics of this bacterium, combined with its physiological requirements, underscore its specialization for survival in the gastric ecosystem. Given its adaptation to a highly specific environment, Helicobacter pylori strain 22368 may be influenced by the host's diet and gastric secretions, making it an intriguing subject for studying host-microbe interactions. This strain serves as a model for understanding the complexities of microbial life in acidic environments and highlights the importance of microbial adaptations in maintaining ecological balance within host-associated habitats.

Taxonomy

KingdomPseudomonadati
PhylumCampylobacterota
ClassEpsilonproteobacteria
OrderCampylobacterales
FamilyHelicobacteraceae
GenusHelicobacter
SpeciesHelicobacter pylori
Strain22368

Profile

Physiology
Gram staining propertiesNegative
ShapeSpirilla
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Helicobacter pylori str. 22368
Image source: Wikipedia/Wikimedia
Ecology, Host, and Life Cycle
Oxygen requirementsMicroaerophilic
Optimal temperature37
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens, Gallus gallus, Aves
Cell arrangementSingles
SporulationNot Available
Energy sourceNot Available
PathogenicityHuman

Genome Summary

Helicobacter pylori strain 22368 scaffold_9, whole genome shotgun

Gene Summary

Adenine Count

498891 bp

Thymine Count

510619 bp

Guanine Count

314876 bp

Cytosine Count

327778 bp

Genome Length

1652164 bp

Protein-coding Genes

1481 genes

Non-Coding Genes

42 genes

# of Chromosomes/Plasmids

1

Genes

NameLocus TagUniProt IDStrand OrientationGene Start/EndProtein Molecular Weight
hypothetical proteinBB403_01250Not AvailableNegative258152 - 25876022602.7
7-alpha-hydroxysteroid dehydrogenaseBB403_01255Not AvailableNegative258770 - 25955828577.2
4-hydroxy-tetrahydrodipicolinate synthaseBB403_01260Not AvailableNegative259555 - 26045733270.5
proteaseBB403_01265Not AvailableNegative260472 - 26180650313.5
dihydroorotate dehydrogenase (quinone)BB403_01270Not AvailableNegative261803 - 26285838874.1
rna degradosome polyphosphate kinaseBB403_01275Not AvailableNegative262896 - 26492377999.8
Trna-proNot AvailableNot AvailablePositive265017 - 265094Not Available
carbonic anhydraseBB403_03960Not AvailableNegative265928 - 26667128255.7
sugar transporterBB403_03965Not AvailablePositive266943 - 26811843163.1
hypothetical proteinBB403_03970Not AvailablePositive268287 - 26966651530.5

Displaying genes 251 – 260 of 1523 in total

Metabolites

0 records
Metabolite IDMetabolite nameStructureCAS number
No metabolites foundTry different search terms or mass values.

Displaying 0 metabolites

Health Effects

Health ConditionRelationReference
Chronic gastric inflammationCausesPMC10226649
Gastric cancerCausesPMC10226649
Gastric ulcersCausesPMC10420633
Stomach carcinomaCausesPMC10420633
UlcersCausesPMC10420633
AdenocarcinomaCausesPMC10420633
Mucosa-associated lymphoid tissue lymphomaCausesPMC10420633
GerdCausesPMC10712878
GastritisCausesPMC10712878
Gastric cancerCausesPMC10732068

Displaying health effects 1 – 10 of 94 in total