Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
transcriptional regulatorHI_RS07695P44216+1568867 - 156930016805.6
hypothetical proteinHI_RS07700P44217+1569309 - 156981519213.6
Putative n-acetylmuramoyl-l-alanine amidaseHI_RS07705P44218+1569897 - 157044119915.6
Hypothetical proteinHI_RS07710P44219+1570448 - 15707089464.15
duf2681 domain-containing proteinHI_RS07715P44220+1570705 - 15709599773.83
trar/dksa family transcriptional regulatorHI_RS07720P44221+1571077 - 15713048405.74
duf2730 domain-containing proteinHI_RS07725P44222+1571304 - 157163012161.7
Hypothetical proteinHI_RS07730O86242+1571635 - 157194311648.9
Hypothetical proteinHI_RS07735P44223+1571955 - 157252421017.3
Portal proteinHI_RS07740P44224+1572524 - 157405057193.9

Displaying genes 41 – 50 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm0004099L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioateC15H25N4O8Chemical structure of L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioateNot available
Average389.386Da
Monoisotopic389.167787361Da
BASm0004122ADP-L-glycero-beta-D-manno-heptoseC17H25N5O16P2Chemical structure of ADP-L-glycero-beta-D-manno-heptoseNot available
Average617.355Da
Monoisotopic617.078250901Da
BASm0004172(R)-4'-phosphopantetheineC11H21N2O7PSChemical structure of (R)-4'-phosphopantetheineNot available
Average356.33Da
Monoisotopic356.081806356Da
BASm0004386N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphateC63H103NO12P2Chemical structure of N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphateNot available
Average1128.461Da
Monoisotopic1127.696649Da
BASm0004925UDP-N-acetyl-alpha-D-muramateC20H28N3O19P2Chemical structure of UDP-N-acetyl-alpha-D-muramateNot available
Average676.395Da
Monoisotopic676.080870429Da
BASm00050742-(4-dimethylaminophenyl)diazenylbenzoateC15H14N3O2Chemical structure of 2-(4-dimethylaminophenyl)diazenylbenzoateNot available
Average268.297Da
Monoisotopic268.109150283Da
BASm00055001-octadecanoyl-sn-glycero-3-phosphateC21H41O7PChemical structure of 1-octadecanoyl-sn-glycero-3-phosphateNot available
Average436.5198Da
Monoisotopic436.2589902Da
BASm0005774alpha-D-glucosamine 6-phosphateC6H13NO8PNot available3616-42-0
Average258.143Da
Monoisotopic258.038426961Da
BASm0006661UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamineC43H75N3O20P2Chemical structure of UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamineNot available
Average1016.0112Da
Monoisotopic1015.441915Da
BASm0007001UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamateC28H39N5O23P2Chemical structure of UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamateNot available
Average875.582Da
Monoisotopic875.1533009Da

Displaying 71–80 of 188 metabolites