Haemophilus influenzae Rd KW20

Gram-negativeRodNon-motileAerobe; facultative anaerobe

Kingdom

Pseudomonadati

Phylum

Pseudomonadota

Class

Gammaproteobacteria

Order

Pasteurellales

Family

Pasteurellaceae

Genus

Haemophilus

Description

Haemophilus influenzae Rd KW20 is a Gram-negative, rod-shaped bacterium that thrives optimally at a temperature of 35-37 °C. As a chemoheterotroph, it derives its energy from organic compounds, relying on the organic matter present in its environment for growth. This microbe is primarily found in the human respiratory tract, specifically in the nasopharynx and can also be isolated from various other body sites, including the ears, lungs, and sinuses. Classified as a facultative anaerobe, it can live in both aerobic and anaerobic conditions, making it adaptable to a range of environments within the host. H. influenzae Rd KW20 is notable for its role in human health; while it is part of the normal flora of the upper respiratory tract in healthy individuals, it can become pathogenic under certain circumstances. It is known to cause a range of infections, including pneumonia, sinusitis, and otitis media, particularly in children and immunocompromised adults.As a strain in the study of bacterial genetics, H. influenzae Rd KW20 has contributed to significant advancements in the understanding of molecular biology and genetics. Remarkably, it was one of the first organisms to have its genome completely sequenced, providing valuable insights into bacterial evolution, pathogenic mechanisms, and antibiotic resistance. Moreover, its relatively simple genetic makeup makes it an ideal model organism for laboratory studies, facilitating research in areas such as gene expression, protein function, and microbial interactions within the host.

Taxonomy

KingdomPseudomonadati
PhylumPseudomonadota
ClassGammaproteobacteria
OrderPasteurellales
FamilyPasteurellaceae
GenusHaemophilus
SpeciesHaemophilus influenzae
StrainRd KW20

Profile

Physiology
Gram staining propertiesNegative
ShapeRod
MobilityNo
Flagellar presenceYes
Number of membranes2
Image of Haemophilus influenzae Rd KW20
Ecology, Host, and Life Cycle
Oxygen requirementsAerobe; facultative anaerobe
Optimal temperature35
Temperature rangeMesophilic
HabitatHostAssociated
Biotic relationshipFree living
Host(s)Homo sapiens
Cell arrangementNot Available
SporulationNot Available
Energy sourceNot Available
PathogenicityYes

Genome Summary

Haemophilus influenzae Rd KW20

Accession NumberNC_000907.1

Gene Summary

Adenine Count

567623 bp

Thymine Count

564241 bp

Guanine Count

347436 bp

Cytosine Count

350723 bp

Genome Length

1830138 bp

Protein-coding Genes

1663 genes

Non-Coding Genes

140 genes

# of Chromosomes/Plasmids

2

Genes

NameLocus TagUniProtStrandCoordinatesMolecular Weight
formate dehydrogenase accessory sulfurtransferase fdhdHI_RS00025P44449-4579 - 539130045.6
formate dehydrogenase-n subunit alphaHI_RS00030P46448+5662 - 8748115307.0
formate dehydrogenase subunit betaHI_RS00035P44450+8750 - 968834070.5
formate dehydrogenase subunit gammaHI_RS00040P44451+9681 - 1039727759.5
formate dehydrogenase accessory protein fdheHI_RS00045P44452+10467 - 1137534225.8
ribosomal protein s18-alanine n-acetyltransferaseHI_RS00050P44305-11414 - 1185416746.3
dna polymerase iii subunit psiHI_RS00055P43750-11857 - 1226115718.8
16s rrna (guanine(1207)-n(2))-methyltransferase rsmcHI_RS00060P44453+12367 - 1335937063.2
gtpase eraHI_RS00065A5UFI7-13423 - 1433134356.5
ribonuclease iiiHI_RS00070P44441-14328 - 1501125729.0

Displaying genes 91 – 100 of 3606 in total

Pathways

25 pathways

Metabolites

188 records
Metabolite IDMetabolite nameStructureCAS number
BASm0019198PS(18:0/18:1(9Z))C42H80NO10PChemical structure of PS(18:0/18:1(9Z))NULL
Average790.073Da
Monoisotopic789.551984778Da
BASm0019212PS(16:0/18:1(9Z))C40H76NO10PChemical structure of PS(16:0/18:1(9Z))NULL
Average762.019Da
Monoisotopic761.520684649Da
BASm0019214PS(16:1(9Z)/18:1(9Z))C40H74NO10PChemical structure of PS(16:1(9Z)/18:1(9Z))NULL
Average760.003Da
Monoisotopic759.505034585Da
BASm0020025myristoyl-CoAC35H62N7O17P3SChemical structure of myristoyl-CoA3130-72-1
Average977.89Da
Monoisotopic977.313573819Da
BASm0020027oleoyl-CoAC39H68N7O17P3SChemical structure of oleoyl-CoA1716-06-9
Average1031.98Da
Monoisotopic1031.360524011Da
BASm0020161PA(12:0/16:0)C31H61O8PChemical structure of PA(12:0/16:0)NULL
Average592.785Da
Monoisotopic592.41040544Da
BASm0020162PA(12:0/16:1(9Z))C31H59O8PChemical structure of PA(12:0/16:1(9Z))NULL
Average590.7691Da
Monoisotopic590.394755376Da
BASm0020164PA(14:1(9Z)/16:0)C33H63O8PChemical structure of PA(14:1(9Z)/16:0)NULL
Average618.8223Da
Monoisotopic618.426055504Da
BASm0020166PA(16:1(9Z)/18:1(9Z))C37H69O8PChemical structure of PA(16:1(9Z)/18:1(9Z))NULL
Average672.9127Da
Monoisotopic672.473005696Da
BASm0020169PA(18:0/18:1(9Z))C39H75O8PChemical structure of PA(18:0/18:1(9Z))384833-24-3
Average702.9818Da
Monoisotopic702.519955888Da

Displaying 161–170 of 188 metabolites